2-二氟溴甲基-1,3-苯并噻唑的简便合成  

A Convenient Syhthesis of 2-Bromodifluoromethyl Benzo-1,3-Thiazoles

作　　者：徐荣福 廖富民 蔡颖 刘晋彪[1] XU Rongfu;LIAO Fumin;CAI Ying;LIU Jinbiao(Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry, Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, China)

机构地区：[1]江西理工大学材料冶金化学学部江西省功能分子材料化学重点实验室,江西赣州341000

出　　处：《合成化学》2022年第7期588-592,共5页Chinese Journal of Synthetic Chemistry

基　　金：江西理工大学博士启动基金资助项目(jxxjbs18050)。

摘　　要：本文应用二氟溴乙酸作为二氟溴甲基的合成子,实现了2-巯基芳胺与二氟溴乙酸的缩合反应合成2-二氟溴甲基-1,3-苯并噻唑。该反应以5当量二氟溴乙酸,氯苯为溶剂,于100℃下与2-巯基芳胺反应18~40 h,产率高达88%。目标产物通过核磁共振和高分辨质谱表征。该反应条件温和,是对现有合成2-二氟溴甲基-1,3-苯并噻唑的良好补充。A convenient synthesis of 2-bromodifluoromethyl benzo-1,3-thiazoles under mild conditions has been reported in this paper.A mixture of 2-SH substituted arylaniline(0.3 mmol),bromodifluoroacetic acid(1.5 mmol)was stirred at 100℃in chlorobenzene(3 mL)for 18~40 h.The highest yield is up to 88%.Target products were characterized by nuclear magnetic resonance and high resolution mass spectrometry.The mild condition of the reaction will make it as a valuable alternative to current available methods for the preparation of 2-bromodifluoromethyl benzo-1,3-thiazoles.

关 键 词：二氟溴乙酸 2-氨基苯硫酚 2-二氟溴甲基-1 3-苯并噻唑 合成 

分 类 号：O621.3[理学—有机化学]