甲基丙烯酸二烷氨基乙酯的合成  

Synthesis of Dialkylaminoethyl Methacrylate

作　　者：刘辉 张晓梅[1,2] LIU Hui;ZHANG Xiaomei(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;Department of Chemistry, Xihua University, Chengdu 610039, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]西华大学化学系,四川成都610039 [3]中国科学院大学,北京100049

出　　处：《合成化学》2022年第7期593-596,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21672208)。

摘　　要：采用直接酯缩合的方法,以甲基丙烯酸为原料合成了两种长链取代的甲基丙烯酸二烷氨基乙酯化合物。通过条件优化确定最佳反应条件为n(甲基丙烯酸)∶n(二取代乙醇胺)∶n(DMAP)∶n(EDCI)=1.01∶1.00∶0.20∶1.01,在该反应条件下,室温反应12 h合成甲基丙烯酸N-十二烷基-N-甲氨基乙酯和甲基丙烯酸N-十六烷基-N-甲氨基乙酯,产率分别为93%和91%。Two long-chain substituted dialkylaminoethyl methacrylate compounds were synthesized using the method of ester condensation of methacrylic acid.The optimal reaction conditions were obtained as follows:n(methacrylic acid)∶n(disubstituted ethanolamine)∶n(DMAP)∶n(EDCI)=1.01∶1.00∶0.20∶1.01,and the reaction was carried out at room temperature for 12 h.Under this conditions,2-(dodecyl(methyl)amino)ethyl methacrylate and 2-(hexadecyl(methyl)amino)ethyl methacrylate can be obtained with yields of 93%and 91%,respectively.

关 键 词：甲基丙烯酸 酯化反应 N-甲基乙醇胺 合成 

分 类 号：TQ413.23[化学工程] O62[理学—有机化学]