沙参麦冬汤联合卡介菌多糖核酸治疗肺结核患者的效果  

Effects of Shashen Maidong decoction combined with BCG polysaccharide nucleic acid in treatment of patients with pulmonary tuberculosis

作　　者：张志杰[1] ZHANG Zhijie(Henan Infectious Disease Hospital,Department of Respiration of the Sixth People’s Hospital of Zhengzhou,Zhengzhou 450000Henan,China)

机构地区：[1]河南省传染病医院郑州市第六人民医院呼吸科,河南郑州450000

出　　处：《中国民康医学》2022年第12期130-132,145,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察沙参麦冬汤联合卡介菌多糖核酸治疗肺结核患者的效果。方法:选取102例肺结核患者为研究对象,按照随机数字表法分为对照组和观察组各51例。观察组予以沙参麦冬汤联合卡介菌多糖核酸治疗,对照组予以卡介菌多糖核酸治疗,比较两组治疗前后临床症状积分、T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平和炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-4(IL-4)、γ-干扰素(INF-γ)]水平。结果:治疗后,两组咳嗽咳痰、食欲不振、胸痛、午后低热、盗汗等临床症状积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,两组CD8^(+)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、CRP、IL-4水平均低于治疗前,且观察组低于对照组,两组INF-γ水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为7.84%(4/51),与对照组的11.76%(6/51)比较,差异无统计学意义(P>0.05)。结论:沙参麦冬汤联合卡介菌多糖核酸治疗肺结核患者可降低临床症状积分,以及改善T细胞亚群指标和炎性因子水平,优于单纯卡介菌多糖核酸治疗效果。Objective:To observe effects of Shashen Maidong decoction combined with BCG polysaccharide nucleic acid in treatment of patients with pulmonary tuberculosis.Methods:102 patients with pulmonary tuberculosis were selected as the research objects and were divided into control group and observation group according to the random number table method,51 cases in each group.The observation group was treated with Shashen Maidong decoction combined with BCG polysaccharide nucleic acid,while the control group was treated with BCG polysaccharide nucleic acid.The clinical symptom scores,the T cell subset indexes(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels and the inflammatory factor indexes[(Tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-4(IL-4),interferonγ(INF-γ)]levels were compared between the two groups.Results:After the treatment,the scores of clinical symptoms such as cough and expectoration,loss of appetite,chest pain,afternoon low-grade fever,and night sweats in the two groups were all lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+) in the two groups were higher than before the treatment,and those of the observation group were higher than those of the control group;the CD8^(+) levels in the two groups were lower than before the treatment,and that of the observation group was lower than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α,CRP and IL-4 in the two groups were lower than before the treatment,and those of the observation group were lower than those of the control group;the INF-γlevels in the two groups were higher than before the treatment,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the

关 键 词：沙参麦冬汤 肺结核 卡介菌多糖核酸 T细胞亚群 炎性因子 不良反应 

分 类 号：R521[医药卫生—内科学]