术前血清r-GT、ALP水平与晚期肝癌患者经导管肝动脉化疗栓塞术疗效的相关性  

Correlation between preoperative serum r-GT,ALP levels and the efficacy of transcatheter hepatic artery chemoembolization in patients with advanced hepatocellular carcinoma

作　　者：李艳秋 刘培明[1] 范德胜[1] LI Yan-qiu;LIU Pei-ming;FAN De-sheng(Department of Medical Laboratory,Huaibei Miners General Hospital,Huaibei 235000,Anhui,China)

机构地区：[1]淮北矿工总医院医学检验科,安徽淮北235000

出　　处：《川北医学院学报》2022年第7期898-901,913,共5页Journal of North Sichuan Medical College

基　　金：安徽省淮北市2018年科技攻关计划项目(rj201834)。

摘　　要：目的:探讨术前血清r-谷氨酰转肽酶(r-GT)、碱性磷酸酶(ALP)水平与晚期肝癌患者经导管肝动脉化疗栓塞术(TACE)疗效的相关性。方法:80例晚期肝癌患者设为观察组,同期80名健康体检者设为对照组。采集观察组患者治疗前两周和对照组体检当日的空腹静脉血,分别采用速率法和荧光法检测两组血清r-GT和ALP水平,并进行差异性分析。TACE术后28 d复查增强CT,根据TACE疗效将80例患者分为有效组和无效组,比较两组术前血清r-GT和ALP水平。采用Spearman相关系数分析术前血清r-GT和ALP水平与晚期肝癌患者TACE疗效的相关性;采用Logistic回归方程分析术前血清r-GT和ALP水平是否是影响晚期肝癌患者TACE疗效的相关因素,并绘制受试者工作特征(ROC)曲线评估术前血清r-GT和ALP单独及联合检测对晚期肝癌患者TACE疗效的预测价值。结果:观察组术前血清r-GT和ALP水平均高于对照组(P<0.05)。有效组术前血清r-GT和ALP水平均低于无效组(P<0.05)。Spearman相关性分析显示,晚期肝癌患者术前血清r-GT和ALP水平与TACE疗效呈负相关性(P<0.05)。Logistic回归分析显示,术前血清r-GT、ALP水平均是晚期肝癌患者TACE疗效的影响因素(P<0.05)。ROC曲线显示,术前血清r-GT、ALP水平预测晚期肝癌患者TACE疗效的ROC曲线下面积(AUC)分别为0.762、0.765,两项联合预测的AUC值为0.880,均大于两项单独检测(P<0.05)。结论:晚期肝癌患者血清r-GT、ALP水平高于健康人群,其TACE疗效与术前血清r-GT、ALP水平具有一定相关性,两项指标联合检测可在一定程度上提高晚期肝癌患者TACE疗效预测效能。Objective:To investigate the correlation between preoperative serum r-glutamyl transpeptidase(r-GT),alkaline phosphatase(ALP)levels and the efficacy of transcatheter hepatic arterial chemoembolization(TACE)in patients with advanced hepatocellular carcinoma.Methods:80 patients with advanced hepatocellular carcinoma were selected for the study(observation group),and 80 healthy checkups during the same period were used as the control group.Fasting venous blood was collected from patients with advanced hepatocellular carcinoma 2 weeks before treatment and from the control group on the day of physical examination,and the serum r-GT and ALP levels of the two groups were measured by the rate method and fluorometric method,respectively,and analyzed for differences.Enhanced CT was reviewed 28 d after TACE,and 80 patients were divided into effective and ineffective groups according to the efficacy of TACE,and the preoperative serum r-GT and ALP levels were compared between the two groups.Spearman's correlation coefficient was used to analyze the correlation between preoperative serum r-GT and ALP levels and the efficacy of TACE in patients with advanced hepatocellular carcinoma.Logistic regression equations were used to analyze whether preoperative serum r-GT and ALP levels were correlates of TACE efficacy in patients with advanced hepatocellular carcinoma,and subject operating characteristic(ROC)curves were plotted to assess the predictive value of preoperative serum r-GT and ALP testing alone and in combination on TACE efficacy in patients with advanced hepatocellular carcinoma.Results:The preoperative serum r-GT and ALP levels in the observation group were higher than those in the control group(P<0.05).The preoperative serum r-GT and ALP levels in the effective group were lower than those in the ineffective group(P<0.05).Spearman correlation analysis showed that preoperative serum r-GT and ALP levels were negatively correlated with TACE efficacy in patients with advanced hepatocellular carcinoma(P<0.05).Logistic regress

关 键 词：晚期肝癌 经导管肝动脉化疗栓塞术 R-谷氨酰转肽酶 碱性磷酸酶 临床疗效 

分 类 号：R735.7[医药卫生—肿瘤]