腰椎间盘退变动物造模研究进展  

Research progress on animal model of lumbar disc degeneration

作　　者：柯建新 林境毅 苏再发 KE Jianxin;LIN Jingyi;SU Zaifa(Fujian University of Traditional Chinese Medicine,Fujian,Fuzhou,351022,China;Quanzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Quanzhou,Fujian,362000,China)

机构地区：[1]福建中医药大学,福建福州351022 [2]福建中医药大学附属泉州市中医院,福建泉州362000

出　　处：《当代医学》2022年第17期184-187,共4页Contemporary Medicine

摘　　要：近年来,腰椎间盘突出症(LDH)患者发病年龄趋于年轻化,且人数逐年增加,严重影响人们的日常生活和工作。但目前LDH的病因和发病机制仍有待探查和研究,设计与构建动物模型,对比性强的动物模型成为研究椎间盘退变的关键和基础。本文针对近年来我国腰椎间盘退变模型研究工作的进展和各种模型在应用中的优劣势进行总结和分析,并进行展望。In recent years,the age of onset of lumbar disc herniation(LDH)tends to be younger,and the number of patients increases year by year,which seriously affects people's daily life and work.However,the etiology and pathogenesis of LDH still need to be explored and studied.The design and construction of animal models have become the key and basis for the study of intervertebral disc degeneration.This paper summarizes and analyzes the research progress of lumbar disc degeneration models in China in recent years and the advantages and disadvantages of various models in application,and looks forward to the future.

关 键 词：腰椎间退变 动物模型 研究进展 

分 类 号：R681.53[医药卫生—骨科学] R-332[医药卫生—外科学]