高龄孕产妇阴道微生态状况及妊娠结局的临床研究  

Clinical study on the vaginal microbiota status and pregnancy outcome in women with advanced matemal age

作　　者：陈静[1] 李云霞[1] 陈宇宁[1] 李仁华 CHEN Jing;LI Yunxia;CHEN Yuning;LI Renhua(Department of Clinical Laboratory,Xindu District of People′s Hospital,Chengdu,Sichuan 610500,China)

机构地区：[1]成都市新都区人民医院医学检验科,四川成都610500

出　　处：《现代医药卫生》2022年第14期2355-2358,共4页Journal of Modern Medicine & Health

基　　金：四川省医学科研课题计划项目(S19076)。

摘　　要：目的探讨高龄孕产妇阴道微生态状况及其妊娠结局,为减少不良妊娠结局的发生提供实验室依据。方法选取2020年1—12月在该院产科住院的213名高龄(分娩年龄≥35岁)孕产妇作为高龄组,选择同期在该院产科住院的975名非高龄(分娩年龄<35岁)孕产妇作为非高龄组,比较2组的孕次、产次、早产(孕周<37周)率、绒毛膜羊膜炎、胎膜早破、产褥期感染发生率;比较2组新生儿窒息、感染发生率;比较2组的微生态平衡率、清洁度异常率、白细胞酯酶阳性率、乳杆菌缺乏率、滴虫性阴道炎检出率、霉菌性阴道炎检出率和细菌性阴道炎检出率。结果高龄组孕产妇早产、绒毛膜羊膜炎、胎膜早破和产褥期感染的发生率高于非高龄组,差异均有统计学意义(P<0.05)。高龄组新生儿窒息和感染发生率高于非高龄组,差异有统计学意义(P<0.001)。高龄组孕产妇阴道微生态平衡率低于非高龄组,差异有统计学意义(P<0.001)。高龄组孕产妇阴道清洁度异常率、白细胞酯酶阳性率、乳杆菌缺乏率和细菌性阴道炎、滴虫性阴道炎、霉菌性阴道炎的检出率均高于非高龄组,差异有统计学意义(P<0.05)。结论高龄孕产妇不良妊娠结局发生率高于非高龄孕产妇,且高龄孕产妇比非高龄孕产妇更易出现阴道微生态失衡现象。Objective To explore the vaginal microbiota status and pregnancy outcomes in women with advanced maternal age(AMA),so as to provide laboratory evidence for reducing the occurrence of adverse pregnancy outcomes.Methods A total of 213 AMA pregnant women(delivery age≥35 years old)hospitalized in the obstetrics department of the hospital from January to December 2020 were selected as the AMA group,and 975 non-AMA(NMA)pregnant women(delivery age<35 years old)hospitalized in the obstetrics department of the hospital in the same period were selected as the NMA group.The gestation times,parity,incidence of preterm birth(gestcetional week<37 weeks),chorioamnionitis,premature rupture of membranes and puerperal infection were compared between the two groups.The incidence of neonatal asphyxia and newborn infant infection were compared between the two groups.The microecological balance rate,abnormal cleanliness rate,white blood cell esterase positive rate,lactobacillus deficiency rate,trichomonas vaginitis detection rate,fungal vaginitis detection rate,and bacterial vaginitis detection rate were compared between the two groups.Results The incidences of premature delivery,chorioamnionitis,premature rupture of membranes and puerperal infection in the AMA group were higher than those in the NMA group,the differences were statistically significant(P<0.05).The incidences of neonatal asphyxia and neonatal infection in the AMA group were higher than those in the NMA group,the differences were statistically significant(P<0.001).The vaginal microecological balance rate of pregnant women in the AMA group was lower than that in the NMA group,the difference was statistically significant(P<0.001).The abnormal rate of cleanliness,the abnormal rate of white blood cell count,the rate of lactobacillus deficiency,bacterial vaginitis,trichomonas vaginitis,fungal vaginitis detection rates in the AMA group were higher than those in the NMA group,and the differences were statistically significant(P<0.05).Conclusion The incidence of adverse pregn

关 键 词：高龄孕产妇 阴道微生态 细菌性阴道炎 不良妊娠结局 

分 类 号：R446.1[医药卫生—诊断学]