CRP、TNF-α、IL-1β联合检测在创伤性肱骨骨折术后骨化性肌炎中的应用价值  

Value of Combined Detection of CRP,TNF-αand IL-1β in Application of Myositis Ossificans of Patients with Traumatic Humeral Fractures after Surgery

作　　者：李刚[1] 孙劲松[1] 李伟 熊科 LI Gang;SUN Jin-song;LI Wei;XIONG Ke(Department of Orthopedics,People's Hospital of Dujiangyan City,Dujiangyan,Sichuan 611830,China)

机构地区：[1]都江堰市人民医院骨科,四川都江堰611830

出　　处：《解放军医药杂志》2022年第6期59-62,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：四川省科学技术厅科技计划-应用基础研究项目(18YYJC1251)。

摘　　要：目的探讨C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)联合白细胞介素-1β(IL-1β)检测在创伤性肱骨骨折术后骨化性肌炎中的预测价值。方法选取2018年8月—2020年8月收治的行手术治疗的创伤性肱骨骨折162例作为研究组,选取同期健康体检者183例作为对照组。比较2组CRP、TNF-α、IL-1β表达水平;统计创伤性肱骨骨折术后骨化性肌炎发生情况;采用受试者工作特征(ROC)曲线分析CRP、TNF-α、IL-1β及三者联合检测对创伤性肱骨骨折术后发生骨化性肌炎的预测价值,多因素Logistic回归分析创伤性肱骨骨折术后发生骨化性肌炎的影响因素。结果研究组CRP、TNF-α及IL-1β表达水平高于对照组(P<0.01)。162例中术后发生骨化性肌炎41例(25.30%)。根据是否发生骨化性肌炎分为A组41例和B组121例。A组CRP、TNF-α及IL-1β表达水平高于B组(P<0.01)。有暴力康复治疗情况、手术时间≥120 min及CRP、TNF-α、IL-1β异常升高为创伤性肱骨骨折术后发生骨化性肌炎的独立危险因素(P<0.05,P<0.01)。CRP、TNF-α、IL-1β联合检测曲线下面积最大。结论CRP、TNF-α、IL-1β水平在创伤性肱骨骨折患者中呈异常表达状态,是创伤性肱骨骨折术后发生骨化性肌炎的独立危险因素,三者联合检测对评估患者病情变化及术后骨化性肌炎的发生有重要价值。Objective To explore the value of combined detection of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)in prediction of myositis ossificans of patients with traumatic humeral fractures after surgery.Methods A total of 162 patients with traumatic humeral fractures who had been treated with surgeries between August 2018 and August 2020 were selected as research group,and 183 healthy physical examinees at the same period were selected as control group.Expressions of CRP,TNF-αand IL-1βwere compared between two groups,and incidence rates of myositis ossificans after traumatic humeral fracture were calculated.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of combined detection of CRP,TNF-αand IL-1βin prediction of occurrence of myositis ossificans in patients with traumatic humerus fractures after surgery,and multivariate Logistic regression analysis was used to analyze the factors affecting the occurrence of myositis ossificans in patients with traumatic humeral fractures after surgery.Results Expressions of CRP,TNF-αand IL-1βin research group were significantly higher than those in control group(P<0.01).Postoperative myositis ossificans occurred in 41 patients(25.30%)among the 162 patients.According to the occurrence of myositis ossificans,the research group was divided into subgroup A(n=41)and subgroup B(n=121).Expressions of CRP,TNF-αand IL-1βin subgroup A were significantly higher than those in subgroup B(P<0.01).Violent rehabilitation,operative duration equal or more than 120 min,and abnormally elevated CRP,TNF-αand IL-1βwere independent risk factors for myositis ossificans in patients with traumatic humeral fractures after surgery(P<0.05,P<0.01).The area under the receiver operating characteristic(ROC)curve of combined detection of CRP,TNF-αand IL-1βwas the largest.Conclusion CRP,TNF-αand IL-1βlevels are abnormally expressed in patients with traumatic humeral fractures,and the three indexes are independent risk factors for th

关 键 词：肱骨骨折 骨化性肌炎 C反应蛋白 肿瘤坏死因子-α 白细胞介素-1Β 危险因素 

分 类 号：R683.41[医药卫生—骨科学]