艾滋病患者应用复方磺胺甲噁唑致不良反应报告及危险因素分析  

Risk factors analysis and report on adverse drug reactions of compound sulfamethoxazole tablets in AIDS patients

作　　者：邱新野[1] 朱晓虹[1] 尹月[2] 刘炜 王咏梅[1] QIU Xin-ye;ZHU Xiao-hong;YIN Yue;LIU Wei;WANG Yong-mei(Beijing Youan Hospital,Capital Medical University,Beijing 100069,China;Key Laboratory of Carcinogenesis and Translational Research,Ministry of Education/Beijing,Department of Pharmacy,Peking University Cancer Hospital&Institute,Beijing 100142,China)

机构地区：[1]首都医科大学附属北京佑安医院药学部,北京100069 [2]北京大学肿瘤医院暨北京市肿瘤防治研究所药剂科,恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《实用药物与临床》2022年第7期649-652,共4页Practical Pharmacy and Clinical Remedies

基　　金：首都医科大学附属北京佑安医院2021年度院内中青年人才孵育项目(YNKTGL2021002)。

摘　　要：目的探讨复方磺胺甲噁唑致艾滋病患者不良反应的特点,分析危险因素,为临床药物警戒及合理用药提供参考。方法采用回顾性研究方法,统计2019年1月至2020年12月在我院住院并服用复方磺胺甲噁唑的艾滋病患者的基本信息、实验室检查、复方磺胺甲噁唑使用情况、不良反应信息及转归,并进行统计分析。结果308例服用复方磺胺甲噁唑的艾滋病患者共78例发生药物不良反应,其中男性占97.44%。不良反应最常累及器官为血液系统及皮肤。92.31%的患者经对症治疗后不良反应症状好转或痊愈。相关因素分析显示,复方磺胺甲噁唑日剂量>0.96 g(OR=10.402)、CD4^(+)T淋巴细胞计数≤100个/μl(OR=7.690)及HIV病毒载量≥200 copies/ml(OR=49.404)为艾滋病患者服用复方磺胺甲噁唑发生不良反应的独立危险因素(P<0.05)。结论低CD4^(+)T淋巴细胞计数及HIV病毒载量较高的艾滋病患者,使用治疗剂量的复方磺胺甲噁唑,应加强对常见不良反应的监测,并对不良反应及早采取干预措施。Objective To explore the characteristics of adverse drug reactions of compound sulfamethoxazole tablets in AIDS patients and analyze the risk factors,and to provide reference for clinical pharmacovigilance and rational drug use.Methods The basic information,laboratory test indexes,use of compound sulfamethoxazole tablets,adverse drug reactions and outcomes of AIDS patients hospitalized and taking compound sulfamethoxazole tablets in our hospital from January 2019 to December 2020 were analyzed retrospectively.Results Totally 308 AIDS patients were involved,in which 78 patients had adverse drug reactions,and male accounted for 97.44%.The blood system and the skin adverse drug reactions were the most commonly.Adverse drug reactions of 92.31%of the patients were cured.Correlation analysis showed the daily dosage of compound subfamethoxazole tablets>0.96 g(OR=10.402),the CD4^(+)T lymphocyte count≤100/μl(OR=7.690),and the viral load of HIV≥200 copies/ml(OR=49.404)were the independent risk factors for adverse drug reactions of compound sulfamethoxazole tablets in AIDS patients(P<0.05).Conclusion The monitoring of adverse drug reactions should be strengthened and early intervention measures should be taken for AIDS patients with low CD4^(+)T lymphocyte count and high HIV viral load.

关 键 词：复方磺胺甲噁唑 艾滋病 药品不良反应 危险因素 

分 类 号：R969.3[医药卫生—药理学]