温肾补阳法联合抗骨质疏松治疗绝经妇女早期膝骨关节炎疗效观察  

Observation of Curative Effect of Warming Kidney and Nourishing Yang Method Combined with Anti-osteoporosis in the Treatment of Early Knee Osteoarthritis in Postmenopausal Women

作　　者：陈贤毅 庄至坤 郭金花 李慧芬[2] 吴昭克 CHEN Xian-yi;ZHUANG Zhi-kun;GUO Jin-hua;LI Hui-fen;WU Zhao-ke(Quanzhou Medical Junior College,Quanzhou 362000,China;Quanzhou Orthopaedic Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Quanzhou 362000,Fujian,China)

机构地区：[1]泉州医学高等专科学校,福建泉州362000 [2]福建中医药大学附属泉州市正骨医院,福建泉州362000

出　　处：《云南中医中药杂志》2022年第7期31-35,共5页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：福建省泉州市科技计划项目(2020N060S);福建省泉州市科技计划项目(2020C030R)。

摘　　要：目的探讨温肾补阳法联合抗骨质疏松治疗对骨质疏松绝经妇女早期膝骨关节炎的临床疗效。方法选取肾阳虚型绝经妇女早期膝骨关节炎患者65例为研究对象,对照组予以碳酸钙D3片、骨化三醇与阿仑磷酸钠抗骨质疏松治疗,观察组在上述药物治疗基础上联合壮骨通痹丸。以VAS评分、WOMAC骨关节炎指数、中医证候积分、骨密度检测与骨代谢指标评价临床疗效。结果治疗6个月后,2组VAS评分、WOMAC骨关节炎指数、中医证候积分均显著低于治疗前水平,组间比较差异有统计学意义(P<0.05);2组腰椎及股骨颈骨密度变化较治疗前升高,组间比较差异无统计学意义(P>0.05);2组骨代谢指标TPINP与β-Cro水平较治疗前均明显下降,组间比较差异有统计学意义(P<0.05),25-OH VID水平较治疗前升高,组间比较差异无统计学意义(P>0.05)。结论抗骨质疏松治疗可以改善骨质疏松绝经妇女早期膝骨关节炎的临床症状,联合使用以温肾补阳为主要功效的壮骨通痹丸有助于提升临床疗效。Objective:To study the clinical effect of warming kidney and nourishing yang method combined with anti-osteoporosis treatment on early knee osteoarthritis in postmenopausal women.Methods:65 patients with early knee osteoarthritis in postmenopausal women with kidney-yang deficiency were selected as the research objects.The control group was treated with calcium carbonate D3 tablets,calcitriol and sodium alendronate for anti-osteoporosis treatment,and the observation group was added Zhuanggutongbi pills on the base of the above drugs.The clinical effect was evaluated by VAS score,WOMAC osteoarthritis index,TCM syndrome score,bone mineral density detection and bone metabolism index.Results:After 6-month treatment,the VAS scores,WOMAC osteoarthritis index,and TCM syndrome scores in the two groups were significantly lower than those before treatment,and the difference between the two groups was statistically significant(P<0.05).The changes of lumbar vertebra and neck bone mineral density were higher than those before treatment,and there was no significant difference between the two groups(P>0.05).The levels of bone metabolism indexes TPINP andβ-Cro in the two groups were significantly decreased compared with those before treatment,and the difference between the two groups was statistically significant(P<0.05).The level of 25-OH VID was higher than that before treatment,and there was no significant difference between the groups(P>0.05).Conclusion:The anti-osteoporosis treatment can improve the clinical symptoms of early knee osteoarthritis in osteoporotic postmenopausal women,and the combined use of Zhuanggutongbi Pills with warming kidney and nourishing yang as the main effect can help to improve the clinical effect.

关 键 词：温肾补阳法 壮骨通痹丸 膝骨关节炎 骨质疏松 

分 类 号：R684.3[医药卫生—骨科学]