黄芪饮片中5种重金属的含量测定  

Determination of Heavy Metals in Astragalus membranaceus(Fisch.)Bunge.

作　　者：黄贵红 HUANG Gui-hong(Quanzhou Institute for Food and Drug Control,Quanzhou 362300,China)

机构地区：[1]泉州市食品药品检验所中药室,福建泉州362300

出　　处：《海峡药学》2022年第7期30-33,共4页Strait Pharmaceutical Journal

摘　　要：目的测定黄芪饮片中铅(Pb)、镉(Cd)、砷(As)、汞(Hg)、铜(Cu)5种重金属的含量,并对该测定方法的可行性和准确度进行细致分析。方法参照《中国药典》2020年版四部通则2321铅、镉、砷、汞、铜测定法的第二法,采用微波消解法对样品进行前处理,电感耦合等离子体质谱(ICP-MS)法对黄芪中重金属及有害元素含量进行分析。结果黄芪饮片中5种重金属元素的线性关系良好(r>0.999),定量限为0.0009~0.0351 mg·kg^(-1),回收率为88.0%~107.4%,准确度和精密度均符合痕量分析要求。结论该方法准确、稳定、灵敏度较高,适合中药饮片中重金属含量的检测。OBJECTIVE The contents of lead(Pb),cadmium(Cd),arsenic(As),mercury(Hg),copper(Cu)in Astragalus decoction pieces were determined,and the feasibility and accuracy of the method were analyzed.METHODS According to the second method for determination of Lead,cadmium,arsenic,mercury and copper in The Fourth General Rule 2321 of Pharmacopoeia of the People′s Republic of China(2020 edition),the samples were pretreated by microwave digestion method and the contents of heavy met als and harmful elements in Astragalus were analyzed by inductively coupled plasma mass spectrometry(ICP-MS).RESULTS The linear relationship of five heavy met als in Radix Astragali pieces was good(r>0.999),the limit of quantification was 0.0009-0.0351 mg·kg^(-1),and the recoveries were 88.0%-107.4%.The accuracy and precision met the requirements of trace analysis.CONCLUSION The method is accurate,stable,sensitive and suitable for the detection of heavy metals in Chinese traditional medicine decoction pieces.

关 键 词：电感耦合等离子体质谱法 中药饮片 重金属 含量测定 

分 类 号：R284[医药卫生—中药学]