肉鸡骨骼发育的调控机制  

Regulation Mechanism of Bone Development in Broilers

作　　者：王翠月 李明睿 高玉时[1] 陈大伟[1] WANG Cuiyue;LI Mingrui;GAO Yushi;CHEN Dawei(Jiangsu Institute of Poultry Science, Yangzhou 225125, China;Shandong Agricultural University,Tai’an 271018, China;Shanxi Agricultural University, Taigu 030801, China)

机构地区：[1]江苏省家禽科学研究所,扬州225125 [2]山东农业大学,泰安271018 [3]山西农业大学,太谷030801

出　　处：《畜牧兽医学报》2022年第7期2057-2065,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：江苏现代农业产业技术体系建设专项资金资助JATS[2021]399。

摘　　要：肉鸡骨骼发育主要是通过软骨内骨化完成的。在软骨内骨化的进程中,生长板软骨细胞经历增殖、肥大、转分化和软骨基质矿化等,最终成骨逐渐取代软骨原基,实现骨骼的线性延长。软骨内成骨是一个复杂精密的过程,由SOX9、RUNX2、MEF2C、OSX、TGF-β、BMP2、FGFs、IHH和PTHrP等多种信号因子和转录因子协调调控,这些调控因子由生长板不同区的软骨细胞表达或特异性的调控软骨细胞的增殖、分化及血管侵入等过程。在家禽养殖中,肉鸡常发腿病且治疗难度大,而有关肉鸡腿病发病机制的研究报道相对较少。本文综述了骨形成过程及具体的分子调控机制,为了解肉鸡腿病的发生以及提供有效治疗方案提供参考。Bone development is mainly accomplished by endochondral ossification in broilers.In the process of endochondral ossification,growth plate chondrocytes undergo proliferation,hypertrophy,transdifferentiation and cartilage matrix mineralization,and eventually osteoblasts gradually replace cartilage primordia to achieve linear bone elongation.Endochondral osteogenesis is a complex and precise process,regulated by multiple signaling and transcription factors such as SOX9,RUNX2,MEF2C,OSX,TGF-β,BMP2,FGFs,IHH and PTHrP,etc.These regulators are expressed by chondrocytes in different zones of the growth plate or specifically regulate chondrocyte proliferation and differentiation,vascular invasion and so on.In poultry breeding,leg disease often occurs in broilers and is difficult to cure,but there are few studies on the pathogenesis of broiler leg disease.This article reviewed the process of bone formation and its specific molecular regulation mechanism,providing reference for understanding the pathogenesis and reasonable treatment of broiler leg disease.

关 键 词：骨骼 生长板 软骨细胞 软骨内骨化 调控因子 肉鸡 

分 类 号：S831.2[农业科学—畜牧学]