中药多糖作为免疫增强剂及其对肠道黏膜影响的研究进展  

Research Progress of Chinese Herbal Polysaccharides as Immunopotentiator and Its Effect on Intestinal Mucosa

作　　者：伯若楠 王晶 刘晓盼 刘明江[1,2] 李金贵 BO Ruonan;WANG Jing;LIU Xiaopan;LIU Mingjiang;LI Jingui(College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China)

机构地区：[1]扬州大学兽医学院,扬州225009 [2]江苏省高校动物重要疫病与人兽共患病防控协同创新中心,扬州225009

出　　处：《畜牧兽医学报》2022年第7期2066-2073,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32002324);江苏省自然科学基金(BK2020945);江苏省高校优势学科建设工程资助项目。

摘　　要：黏膜是机体免疫的第一道防线,口服、滴鼻、点眼等黏膜免疫途径可有效诱导保护性黏膜免疫反应。但目前绝大多数的黏膜免疫疫苗仍未开发,且缺乏安全有效的免疫增强剂。中药多糖已被证实是一类具有促进黏膜免疫效应的生物活性大分子。本文对近年来不同类型的中药多糖作为免疫增强剂及其对肠道黏膜的影响进行综述,旨在为中药多糖作为黏膜免疫增强剂的开发利用提供新思路。Mucosa is the frontline of body immune defense.Protective mucosal immune response can be effectively induced by oral administration,nose drop,ocular routes and other mucosal routes.However,most mucosal immune vaccines have not been developed,and there is a lack of safe and effective immunopotentiator.Chinese herbal polysaccharides have been proved as biologically-active macromolecules to promote mucosal immune response.This paper reviews different mucosal immunopotentiator of Chinese herbal polysaccharides and its effect on intestinal mucosa in recent years,in order to provide new ideas for the development and utilization of Chinese herbal polysaccharides as mucosal immune immunopotentiator.

关 键 词：中药多糖 肠道黏膜免疫 免疫增强剂 

分 类 号：S853.74[农业科学—临床兽医学]