生物信息综合数据库KEGG的应用  

Application of database of Kyoto Encyclopedia of Genes and Genomes,a comprehensive bioinformatics database

作　　者：袁炜[1] 耿辉[2] 王馨笛 蒿花 王亚军[2] 陈新欢 马茂[2] Yuan Wei;Geng Hui;Wang Xindi;Hao Hua;Wang Yajun;Chen Xinhuan;Ma Mao(不详;Department of Cardiology,First Affiliated Hospital of Xi`an Jiaotong University,Xi`an 710061,China)

机构地区：[1]西安交通大学第一附属医院心内科,西安710061 [2]西安交通大学第一附属医院体检部,西安710061 [3]西安交通大学医学部,西安710061

出　　处：《中国循证心血管医学杂志》2022年第6期669-673,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：陕西省基金(2020SF-071);西安交通大学第一附属医院院基金(2020RKX-16);西安交通大学第一附属医院院基金(2021ZYTS-39)。

摘　　要：随着后基因组时代的来临,利用基因表达产物提供的信息,从分子水平理解生物系统的高级功能,如基因导致的各种疾病及表型、作用的信号通路、集成的基因组功能等,是目前亟待解决的问题。近年来,高通量测序技术的进步与完善,产生大量的实用性基因数据库资源,通过计算机完成基因及其表达产物的功能演绎,利用信息技术提供的结果推测蛋白质交互网络在各种细胞活动起的作用,能够解释高层次、复杂细胞通路及活动的本质。但由于基因数量庞大,作用通路复杂,需要一个整合基因组、化学和系统功能信息的平台,帮助人们快速了解目标基因的相关功能及通路信息。KEGG数据库即是一个综合性的生物信息数据库,通过基因相关信息对通路等数据进行可视化展示,并建立了跨物种基因间的联系,直观全面地了解目标基因对应各种生物活动的内在规律。With the advent of post-genomic era,the use of information provided by gene expression products to understand the advanced functions of biological systems at molecular level,such as various diseases and phenotypes caused by genes,signaling pathways,integrated genome functions,etc.,is a urgent problem to be solved at present.In recent years,the advancement and improvement of high-throughput sequencing technology has produced a large number of practical gene database resources.The function deduction of genes and their expression products are completed through computers,and the results provided by information technology are used to infer protein interaction networks.the nature of high-level and complex cell pathways and activities can be explained.However,due to large number and complex pathways of genes,a platform that integrates genomes,chemistry and system function information is needed to help researchers to understand quickly the relevant functions and pathway information of target genes.The database of Kyoto Encyclopedia of Genes and Genomes(KEGG)is a comprehensive biological information database,which visually displays pathways and other data through gene-related information and establishes cross-species genetic connections for understanding intuitively and comprehensively the internal laws of target genes corresponding to various biological activities.

关 键 词：生物信息学 KEGG 信号通路 基因 

分 类 号：R4[医药卫生—临床医学]