常规超声及造影征象与甲状腺乳头状癌BRAF V600E基因突变的相关性及其临床意义  

Correlation of BRAF V600E Mutation and Conventional Ultrasound and Contrast-enhanced Ultrasound Features in Papillary Thyroid Carcinoma and Its Clinical Significance

作　　者：黄梅凤 张丽丽[1] 袁新春[1] 张哲元 郑巍[2] Huang Meifeng;Zhang Lili;Yuan Xinchun;Zhang Zheyuan;Zheng Wei(Department ofUltrasound,The First Affiliated Hospital of Nanchang University,Nanchang 330000,China;Department of Ultrasound,Jiangxi Provincial Children's Hospital,Nanchang 330000,China)

机构地区：[1]南昌大学第一附属医院超声医学科,南昌市330000 [2]江西省儿童医院影像科,南昌市330000

出　　处：《中国超声医学杂志》2022年第6期611-614,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的分析甲状腺乳头状癌(PTC)的超声征象与BRAF V600E基因突变的相关性。方法回顾性分析236例PTC患者的病例资料。根据BRAF V600E基因突变与否分为阳性组及阴性组,对比两组一般资料、常规超声及超声造影(CEUS)征象,分析BRAF V600E基因突变的独立相关因素。结果BRAF V600E基因突变阳性组在微钙化、纵横比、被膜侵犯、增强后大小、增强模式上与阴性组对比有显著差异(P<0.05)。微钙化、纵横比≥1及造影后病灶较前增大是BRAF V600E基因突变的独立相关因素。结论微钙化、纵横比≥1及造影后病灶较前增大与BRAF V600E基因突变有相关性,对早期发现高危PTC具有一定指导意义。Objective To analyze the correlation of BRAF V600 E gene mutation and ultrasound features in papillary thyroid carcinoma(PTC).Methods Clinical data of 236 PTC patients were retrospectively analyzed.According to BRAF V600 E gene mutation,patients were divided into positive group and negative group,general data,conventional ultrasound and contrast-enhanced ultrasound(CEUS)images between the two groups was compared.The independent correlation factors of BRAF V600 E gene mutation were analyzed.Results There were significant differences between positive group and negative group in microcalcification,aspect ratio,membrane invasion,the size of nodules after CEUS and enhancement mode(P<0.05).Microcalcification,aspect ratio≥1 and the size of nodules become bigger after CEUS were independent correlation factors for BRAF V600 E gene mutation.Conclusions Microcalcification,aspect ratio≥1 and the size of nodules become bigger after CEUS were correlated with BRAF V600 E gene mutation.These features have certain guiding significance for early detection of high-risk PTC.

关 键 词：甲状腺乳头状癌 BRAF V600E基因突变 超声造影 

分 类 号：R445.1[医药卫生—影像医学与核医学] R736.1[医药卫生—诊断学]