29例磷化氢中毒者体内总磷化氢分布以及磷化氢中毒特征分析  

Analysis of the Distribution of Total Phosphine and the Characteristics of Phos⁃phine Poisoning in 29 Victims

作　　者：严慧 杜猛[2] 乔正 向平 沈保华 沈敏 刘伟 YAN Hui;DU Meng;QIAO Zheng;XIANG Ping;SHEN Bao-hua;SHEN Min;LIU Wei(Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Ministry of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;Institute of Criminal Science and Technology,Jiading Branch of Shanghai Public Security Bureau,Shanghai 201800,China)

机构地区：[1]司法鉴定科学研究院,上海市法医学重点实验室,司法部司法鉴定重点实验室,上海市司法鉴定专业技术服务平台,上海200063 [2]上海市公安局嘉定区分局刑事科学技术研究所,上海201800

出　　处：《法医学杂志》2022年第2期254-257,共4页Journal of Forensic Medicine

基　　金：上海市自然科学基金资助项目(19ZR1458800);司法部司法鉴定重点实验室资助项目;上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目(19DZ2290900)。

摘　　要：目的对磷化氢中毒者体内总磷化氢的分布进行研究,总结归纳该类中毒案件的特征。方法采用顶空气相色谱-质谱法对16起磷化氢中毒案件中29例中毒者生物样品中的磷化氢及代谢物进行定性和定量分析。结果29例中毒者中有5例为口服磷化铝中毒,24例为吸入磷化氢气体中毒。23例中毒者的体内检材中检出磷化氢代谢物,血液中总磷化氢质量浓度为0.5~34.0μg/mL,磷化氢中毒死者肝组织中总磷化氢质量分数最高达71.0μg/g。另有6例生还的中毒者血液中未检出磷化氢,可能与其磷化氢暴露量较小、血液采样不及时有关。结论口服磷化铝致死者血液和组织中总磷化氢浓度较高,吸入磷化氢中毒死亡案件呈现磷化氢气体暴露时间长、多次暴露、年龄易感等特点。Objective To study the distribution of total phosphine in phosphine poisoning victims and summarize the characteristics of phosphine poisoning cases.Methods The phosphine and its metabolites in the biological samples of 29 victims in 16 phosphine poisoning cases were qualified and quantified by headspace gas chromatography-mass spectrometry.Results Five victims among 29 were poisoned by ingestion of aluminium phosphide and 24 by inhalation of phosphine gas.Phosphine metabolites were detected in the biological samples of 23 victims,and the concentrations of total phosphine in blood ranged 0.5-34.0μg/mL.The total concentration of phosphine in liver tissue was up to 71.0μg/g.Phosphine was not detected in the blood of the other six survived victims,which may be related to the small amount of phosphine exposure and the delay in blood sampling.Conclusion The total concentration of phosphine in blood and tissues caused by aluminum phosphine ingestion is higher than that caused by phosphine gas inhalation.The death cases of phosphine inhalation are characterized by long exposure time,repeated exposures and age susceptibility.

关 键 词：法医毒理学 中毒 磷化氢类 磷化铝 代谢物 组织分布 案例分析 

分 类 号：DF795.1[医药卫生—法医学]