辛伐他汀通过介导衰老巨噬细胞免疫促进成骨和成血管的研究  

Simvastatin Promotes Osteogenesis and Angiogenesis through Mediating Immunology of Senescent Macrophages

作　　者：屈广平 赵宇宇 姚晓红[1] 杭瑞强 QU Guangping;ZHAO Yuyu;YAO Xiaohong;HANG Ruiqiang(Shanxi Key Laboratory of Biomedical Metal Materials,College of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,China)

机构地区：[1]太原理工大学,材料科学与工程学院,医用金属材料山西省重点实验室,太原030024

出　　处：《太原理工大学学报》2022年第4期600-611,共12页Journal of Taiyuan University of Technology

基　　金：中央引导地方科技发展资金资助项目(YDZJSX2021A019);山西省自然科学基金面上资助项目(20210302123100)。

摘　　要：研究辛伐他汀浓度对衰老巨噬细胞生物学行为及其介导的免疫微环境对成骨和成血管功能的影响,并探索在钛表面装载辛伐他汀介导衰老巨噬细胞功能的可行性。结果表明:当药物浓度为0.1μmol/L时,可促进巨噬细胞的增殖并使其极化为促组织愈合的M2表型,有利于巨噬细胞营造促进成骨和成血管的免疫微环境。在钛表面构建的壳聚糖/明胶涂层可装载并缓释辛伐他汀,促进巨噬细胞的活力和增殖。In this article,we mainly investigated the effects of different simvastatin concentrations on the biological behavior of senescent macrophages and the immune microenvironment mediated by them on osteogenic and angiogenic functions.The feasibility of loading simvastatin on titanium surfaces to mediate the function of senescent macrophages was also explored.The results show that when the concentration of the drug was 0.1μmol/L,it promoted the proliferation of macrophages and polarized them to pro-healing M2 phenotype,which is beneficial for macrophages to create an immune microenvironment promoting osteogenesis and angiogenesis.The chitosan/gelatin coating constructed on titanium surface could load and release simvastatin,promoting the viability and proliferation of senescent macrophages.

关 键 词：辛伐他汀 巨噬细胞 钛 免疫微环境 成骨功能 成血管功能 

分 类 号：R965[医药卫生—药理学]