取代甲苯催化氧化合成取代苯甲醛  

Synthesis of Substituted Benzaldehyde by Catalytic Oxidation of Substituted Toluene

作　　者：牛鹏程 茹雨晴 袁世申 高巍伟 NIU Pengcheng;RU Yuqing;YUAN Shishen;GAO Weiwei(Qingdao University of Science and Technology,Qingdao 266045,China)

机构地区：[1]青岛科技大学,山东青岛266045

出　　处：《化学与生物工程》2022年第7期64-68,共5页Chemistry & Bioengineering

基　　金：山东省重点研发计划(专项公益专项)项目(2017GSF17106);山东省自然科学基金项目(ZR2020QB168);青岛科技大学科研基金项目(010029049)。

摘　　要：以对甲氧基甲苯为原料,采用液相催化氧化法合成对甲氧基苯甲醛,考察了反应温度、H_(2)O_(2)浓度、催化剂种类及用量、催化剂重复使用次数对对甲氧基苯甲醛收率的影响,并以不同取代甲苯为底物,探究了取代苯甲醛合成反应的适用性。结果表明,在反应温度为85℃、H_(2)O_(2)浓度为50%、催化剂乙酰丙酮氧钒用量n(乙酰丙酮氧钒)∶n(对甲氧基甲苯)为1∶10的最佳条件下,对甲氧基苯甲醛收率可达86.3%;以不同取代甲苯为底物,均能够顺利得到预期的取代苯甲醛,且甲苯取代基对取代苯甲醛收率有一定的影响。Taking p-methoxyltoluene as a raw material,we synthesized p-methoxybenzaldehyde by a liquid phase catalytic oxidation method,and investigated the effects of reaction temperature,H_(2)O_(2) concentration,type and dosage of catalyst,and catalyst recycle times on the yield of p-methoxybenzaldehyde.Moreover,we explored the applicability of the synthetic reaction of substituted benzaldehyde by using different substituted toluene as substrates.The results show that the yield of p-methoxybenzaldehyde can reach 86.3%under the optimal conditions as follows:the reaction temperature of 85℃,the H_(2)O_(2) concentration of 50%,and the catalyst vanadium oxy acetylacetonate dosage of n(vanadium oxy acetylacetonate)∶n(p-methoxyltoluene)of 1∶10.The expected substituted benzaldehyde can be obtained by using different substituted toluene as substrates,and the substituent groups of toluene have a certain effect on the yield of substituted benzaldehyde.

关 键 词：催化剂 合成 乙酰丙酮氧钒 取代苯甲醛 

分 类 号：O621.3[理学—有机化学] O622.4[理学—化学]