河北省成人跟骨定量超声参数与代谢综合征的相关性  

Association between calcaneal quantitative ultrasound parameters and metabolic syndrome in adults of Hebei province

作　　者：赵晶晶 曹亚景[1] 孙纪新[1] 单广良[2] 张玲[3] 何慧婧[2] 刘括 崔泽[1] ZHAO Jingjing;CAO Yajing;SUN Jixin;SHAN Guangliang;ZHANG Ling;HE Huijing;LIU Kuo;CUI Ze(Department of Chronic Non-Communicable Diseases Prevention and Control, Hebei Province Center for Disease Prevention and Control, Shijiazhuang 050021;Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005;Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China)

机构地区：[1]河北省疾病预防控制中心慢性非传染性疾病防治所,河北石家庄050021 [2]中国医学科学院基础医学研究所,北京100005 [3]首都医科大学公共卫生学院,北京100069

出　　处：《中国骨质疏松杂志》2022年第7期966-971,共6页Chinese Journal of Osteoporosis

基　　金：国家重点研发计划(2016YFC0900600,2016YFC0900603);河北省医学科学研究课题计划(20200697)。

摘　　要：目的 探讨河北省成人跟骨定量超声参数(quantitative ultrasound parameters,QUS)与代谢综合征(metabolic syndrome,MS)之间的关联。方法 用多阶段分层整群抽样方法 抽取河北省20~80岁常住居民进行问卷调查、体格检查和血液生化检测。使用Pegaus超声骨密度仪测量研究对象右跟骨定量超声骨密度参数[声速(speed of sound,SOS)和宽带超声衰减(broadband ultrasonic attenuation,BUA)]。结果 有效样本6206人(男性2426人,女性3780人),平均年龄(48.02±13.49)岁。MS患病率为20.27%。Spearman相关分析结果 显示,男性BUA水平与体质量指数(BMI)和甘油三酯(TG)呈正相关,与收缩压(SBP)和高密度脂蛋白(HDL-c)呈负相关;SOS水平与BMI呈正相关,与空腹血糖(FPG)和TG呈负相关(P均<0.05)。女性BUA水平与BMI和TG呈正相关,与SBP、DBP和HDL-c呈负相关;SOS水平与SBP、DBP、FPG和TG呈负相关(P均<0.05)。调整年龄、民族、文化程度、吸烟和饮酒等因素后,多因素Logistic回归结果 显示男性BUA水平Q_(4)组发生MS的风险是Q_(1)组的1.53倍(95%CI=1.12~2.08),未发现SOS水平与MS的关联(P>0.05)。女性MS发生风险随BUA水平的升高而增高,Q_(2)、Q_(3)和Q_(4)组发生MS的风险分别为Q_(1)组的1.56、1.66和1.74倍,SOS水平Q_(4)组发生MS的风险是Q_(1)组的1.35倍(95%CI=1.01~1.81)。结论 QUS与MS密切相关,尽管目前MS不是骨质疏松症的重要危险因素,但SBP、DBP、FPG和HDL与QUS参数之间的反比关系提示了改善代谢对促进骨骼健康的必要性。Objective To investigate the association between calcaneal quantitative ultrasound parameters(QUS)with metabolic syndrome(MS)in adults of Hebei province.Methods Adults aged 20-80 years old were selected for questionnaire survey,physical examination and blood biochemical testing through multi-stage stratified cluster sampling method.Calcaneal QUS was measured at the right foot by experienced operators with a Pegaus ultrasound equipment.Broadband ultrasonic attenuation(BUA)and speed of sound(SOS)were recorded.Results Among the 6491 adults(2426 males,3780 females),with an average age of 48.02±13.49 years old,the prevalence of MS was 20.27%.Spearman correlation analysis found that,in males,BUA levels were positively correlated with body mass index(BMI)and triglycerides(TG),and negatively correlated with systolic blood pressure(SBP)and high-density lipoprotein(HDL-C).SOS levels were positively correlated with BMI,but were negatively correlated with fasting blood glucose(FPG)and TG(both P<0.05).In females,BUA level was positively correlated with BMI and TG,but negatively correlated with SBP,DBP,and HDL-C.SOS level was negatively correlated with SBP,DBP,FPG,and TG(all P<0.05).Multivariate logistic regression analyses showed that the risk of MS increased with BUA quantile levels after adjusting for age,ethnicity,education level,smoking and drinking etc,with an odds ratio(OR)of 1.53 times(95%CI=1.12-2.08)in Q_(4) group compared to that in Q_(1) group in males.There was no correlation between the risk of MS and SOS level.In females,the risk of MS increased with BUA quantile levels with an odds ratio(OR)of 1.56,1.66,and 1.74 times in Q_(2),Q_(3),and Q_(4) group compared to those in Q_(1) group,respectively,and the risk of MS in Q_(4) group of SOS level was 1.35(95%CI=1.01-1.81)compared to that in Q_(1) group.Conclusion QUS is closely related to MS.Although MS is not an important risk factor for osteoporosis currently,the reverse relationship between SBP,DBP,FPG,HDL and QUS parameters suggests the necessity of improving met

关 键 词：定量超声 代谢综合征 河北省 成年人 

分 类 号：R589[医药卫生—内分泌]