丹参及其活性单体成分调控骨质疏松症相关信号通路的研究进展  

Research progress of Danshen and its active monomer components in regulating osteoporosis-related signal pathways

作　　者：王伟伟 欧志学[2] 章晓云[1] 李时斌 周毅 李统 WANG Weiwei;OU Zhixue;ZHANG Xiaoyun;LI Shibin;ZHOU Yi;LI Tong(Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530000;Guilin Hospital of Traditional Chinese Medicine, Guilin 541002, Guangxi, China)

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530000 [2]桂林市中医医院,广西桂林541002

出　　处：《中国骨质疏松杂志》2022年第7期1057-1062,1092,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(81960803);广西自然科学基金青年基金(2020GXNSFBA159053)。

摘　　要：骨质疏松症是目前临床上常见的一种骨科疾病,其特征是每单位体积的骨量减少,使得骨强度受损,从而导致患骨发生骨折。而现阶段治疗骨质疏松症多以西药为主,但存在如费用高、有不良反应等缺点。近年来,随着中药药理学研究的不断深入,相关人员发现,丹参及其活性单体可调节相关骨性细胞增殖、凋亡以及分化,从而促进骨骼的生长和愈合。然而目前该领域的相关研究较为零散,多数仅仅局限于某个活性单体在某种骨性细胞上的作用,而中医治疗具有多靶点、多途径的特点,因此笔者通过总结近年来丹参及其活性单体在防治骨质疏松方面的相关研究,从整体方面来对丹参的抗骨质疏松机制进行探讨,并总结目前相关研究所存在的一些问题,从而为中医药防治骨质疏松研究提供一些帮助。Osteoporosis is a common orthopedic disease in clinical practice,characterized by a decrease in bone mass per unit volume,which impairs bone strength and leads to bone fractures.At present,western medicine is the main treatment for osteoporosis,but there are disadvantages such as high cost and side effects.In recent years,with the deepening study in the pharmacology of traditional Chinese medicine,relevant researchers have found that salvia miltiorrhiza and its active monomers regulate the proliferation,apoptosis,and differentiation of related bone cells,thereby promoting the growth and healing of bones.However,the current related research in this field is relatively scattered,and most of them are only limited to the effect of a certain active monomer on a certain type of bone cells.Traditional Chinese medicine treatment has the characteristics of multiple targets and multiple pathways.The authors discuss the anti-osteoporosis mechanism of salvia miltiorrhiza from the overall aspect based on related research on the prevention and treatment of osteoporosis with its active monomers,and summarize some problems existing in the current related research,so as to provide some help for the research on the prevention and treatment of osteoporosis with traditional Chinese medicine.

关 键 词：丹参 骨质疏松 骨吸收 骨形成 信号通路 

分 类 号：R681[医药卫生—骨科学] R285[医药卫生—外科学]