镁元素及镁材料在关节软骨损伤修复中的作用及机制研究进展  

Research progress on the role and mechanism of magnesium and magnesium materials in the repair of articular cartilage injury

作　　者：褚云峰[1] 于红燕 杨琪 彭艳斌[1] 陈仲 刘明 于斐[1,3] CHU Yunfeng;YU Hongyan;YANG Qi;PENG Yanbin;CHEN Zhong;LIU Ming;YU Fei(Peking University Shenzhen Hospital, Shenzhen 518036;Binchengqu Shili Hospital, Binzhou 256600, Shandong;National & Local Joint Engineering Research Center of Orthopedic Biomaterials, Shenzhen 518036, China)

机构地区：[1]北京大学深圳医院,广东深圳518036 [2]滨州市滨城区市立医院,山东滨州256600 [3]骨科生物材料国家地方联合工程研究中心,广东深圳518036

出　　处：《中国骨质疏松杂志》2022年第7期1063-1067,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82102568,82102076,82172432,82001319);广东省基础与应用基础研究基金(2021A1515012586,2019A1515110983,2019A1515011290);白求恩·石药骨质疏松科研基金项目(G-X-2020-1107-21);北京大学深圳医院科研启动金项目(KYQD2021099)

摘　　要：软骨损伤是由炎症、创伤、肿瘤等造成的,由于关节软骨自身解剖因素,使其损伤后的愈合能力较差,制备组织工程材料促进软骨损伤修复备受研究者关注。镁元素及镁材料因其良好的生物安全性、生物相容性、可降解性及可获得性受到广泛关注,其在骨关节炎等软骨损伤修复中起到重要作用,笔者就镁元素及镁材料在关节软骨损伤修复中的作用及机制作一综述。Cartilage injury is caused by inflammation,trauma,and tumor.Due to the anatomical factors of articular cartilage,its healing ability is poor.The preparation of tissue engineering materials to promote the repair of cartilage injury has attracted much attention.Magnesium and magnesium materials have attracted extensive attention because of their good biosafety,biocompatibility,degradability,and availability.They play an important role in the repair of cartilage injury such as osteoarthritis.This paper reviews the role and mechanism of magnesium and magnesium materials in the repair of articular cartilage injury.

关 键 词：镁元素 镁材料 关节软骨 损伤修复 

分 类 号：R684.3[医药卫生—骨科学]