近红外光谱在中药中的应用及其抗肿瘤成分分析的研究进展  

Research progress in near-infrared spectroscopic analysis of traditional Chinese medicines and anti-tumor components

作　　者：贺小刚 楚刚辉 HE Xiaogang;CHU Ganghui(Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry,College of Chemistry and Environmental Science,Kashi University,Kashi 844006,China)

机构地区：[1]新疆特色药食用植物资源化学实验室,喀什大学化学与环境科学学院,喀什844006

出　　处：《西北药学杂志》2022年第5期175-181,共7页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:21765012);新疆维吾尔自治区高校科研计划自然科学重点项目(编号:XJEDU2020I016)。

摘　　要：目的总结近红外光谱(NIRs)在中药中的应用及其抗肿瘤成分分析的研究进展。方法通过查阅国内外文献,对NIRs在中药中的研究应用状况、抗肿瘤成分类型的抗肿瘤机制和NIRs用于抗肿瘤成分类型的分析进行总结。结果NIRs在当归、木瓜、锁阳、三七、前胡和菟丝子等中药中的品种分类、产地分析、真伪鉴别和质量检验等方面具有广泛的应用,而且其中部分成分类型具有一定的抗肿瘤作用,NIRs作为一种快速、无损的分析方法,在黄酮类、多糖类、皂苷类、生物碱类、萜类和有机酸类等抗肿瘤成分类型分析中具有很好的应用前景。结论中药中具有各种类型的抗肿瘤成分,NIRs能够分析研究中药并快速分析抗肿瘤成分,方便为其中的抗肿瘤成分的药理研究及临床应用提供技术保障。Objective To summarize the research progress in near-infrared spectroscopic(NIRs)analysis of traditional Chinese medicines and their anti-tumor components.Methods By reviewing the domestic and foreign literatures,the research and application of NIRs in traditional Chinese medicines,the anti-tumor mechanism of anti-tumor component types,and the analysis of NIRs for anti-tumor active components were summarized.Results NIRs have been widely used in variety of classification,origin analysis,authenticity identification and quality inspection of traditional Chinese medicines such as Angelica sinensis,Chaenomeles speciosa,Cynomorium songaricum,Panax notoginseng,Peucedanum and Cuscuta chinensis,and some of the components have certain anti-tumor effects.As a fast and non-destructive analysis method,NIRs have a good application prospect in the analysis of anti-tumor components such as flavonoids,polysaccharides,saponins,alkaloids,terpenoids and organic acids.Conclusion There are various types of anti-tumor active ingredients in traditional Chinese medicines.NIRs can be used to quickly analyze and study the anti-tumor components in traditional Chinese medicines,which can provide technical support for pharmacological research and clinical application of anti-tumor ingredients.

关 键 词：近红外光谱(NIRs) 中药 抗肿瘤成分 抗肿瘤机制 

分 类 号：R282[医药卫生—中药学]