内毒素吸附膜在治疗新型冠状病毒肺炎中的应用进展  

Advance in research on application of endotoxin adsorption membrane in treatment of coronavirus disease 2019

作　　者：焦金梁 布祖克拉·阿布都艾尼 李梦晨 拜合提尼沙·吐尔地[1] Jiao Jinliang;Buzukela Abuduaini;Li Mengchen;Baihetinisha Turdi(Department of Respiratory Intensive Care Unit,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆医科大学第一附属医院呼吸重症监护室,新疆维吾尔自治区乌鲁木齐830054

出　　处：《中华危重病急救医学》2022年第5期538-541,共4页Chinese Critical Care Medicine

基　　金：新疆维吾尔自治区自然科学基金(2016D01C255)。

摘　　要：新型冠状病毒肺炎(新冠肺炎)是由新型冠状病毒(新冠病毒)引起的严重肺部炎症的传染性疾病。2020年1月12日世界卫生组织(WHO)将发现的新冠病毒命名为"2019-nCoV",并将此病毒导致的疾病命名为"COVID-19"。新冠病毒入侵人体后可刺激免疫系统产生大量细胞因子,引发细胞因子风暴,导致严重感染、急性肺损伤和多器官功能衰竭等。因此,理论上清除这些细胞因子的过度产生可避免发生细胞因子风暴,降低危重型新冠肺炎和严重不良预后的发生率。本文通过对以往文献报道脓毒症中产生细胞因子风暴所致病情恶化,以及近期危重型新冠肺炎患者使用内毒素吸附膜治疗的疗效进行分析,进一步提供内毒素吸附膜应用于新冠肺炎治疗的有效临床证据。The new type coronavirus disease 2019(COVID-19)is a contagious disease of severe lung inflammation induced by 2019 novel coronavirus(2019-nCoV).The World Health Organization(WHO)nomenclature of the newly discovered coronavirus was 2019-nCoV and the disease caused by 2019-nCoV was named COVID-19 on January 12,2020.After 2019-nCoV invasion into a human body,it can stimulate the human immune system and engender a large number of cytokines,triggering a cytokine storm,resulting in severe infection,acute lung injury,multiple organ dysfunction,etc.Therefore,theoretically,the removal of over-production of cytokines can avoid the occurrence of cytokine storm and reduce the incidence of severe critical COVID-19 and serious poor prognosis.In this review,the authors systematically reviewed the past published reports related to the occurrence of cytokine storm in sepsis resulting in deterioration of disease situation,and recently they analyzed the therapeutic effects of patients with severe critical COVID-19 using endotoxin adsorption membrane for treatment in the disease course,further providing the effective clinical evidence of applying endotoxin adsorption membrane for treatment of COVID-19.

关 键 词：新型冠状病毒肺炎 细胞因子风暴 内毒素吸附 

分 类 号：R563.1[医药卫生—呼吸系统]