调节性B细胞的作用机制及其在相关疾病中的研究进展  

Progress in the mechanism of regulatory B cells and its role in human diseases

作　　者：郑易[1] 潘丽娜 高宇[2] 谢旦立[1] Zheng Yi;Pan Lina;Gao Yu;Xie Danli(School of Laboratory Medicine and Life Science,Wenzhou Medical University,Wenzhou 325035,China;Department of Dermatology,the Second Affiliated Hospital and Yuying Children′s Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学检验医学院,生命科学学院,温州325035 [2]温州医科大学附属第二医院育英儿童医院皮肤科,温州325027

出　　处：《中华微生物学和免疫学杂志》2022年第6期484-489,共6页Chinese Journal of Microbiology and Immunology

基　　金：浙江省实验动物科技计划项目(2018C37113);温州市基础性科研项目(Y20180146)。

摘　　要：调节性B细胞(regulatory B cells,Bregs)是一群具有免疫调节功能的细胞,通过抑制过度炎症反应从而调节疾病进展,是一种在免疫功能紊乱等状态下发挥重要作用的保护性细胞。本文就其来源、功能、作用机制及其在自身免疫性疾病、感染及肿瘤方面的相关研究进展作一综述。Regulatory B cells(Bregs)are a group of cells with immunoregulatory function.They can regulate the progression of diseases by inhibiting excessive inflammatory responses and serve as critical protective cells in immune disorders and other conditions.This article reviewed the source,function and mechanism of Bregs and its role in autoimmune diseases,infection and tumor.

关 键 词：调节性B细胞 感染 肿瘤 自身免疫性疾病 

分 类 号：R392[医药卫生—免疫学]