左旋聚乳酸-聚己内酯-醋酸纤维素三维微-纳米复合纤维多孔支架材料的制备与生物矿化活性  

Fabrication of polycaprolactone-cellulose acetate-poly(L-lactic acid)three-dimensional micro-nanofibrous porous scaffold composites and its bio-mineralization activity

作　　者：赵瑨云 刘瑞来 胡家朋[1] 穆寄林 付兴平 ZHAO Jinyun;LIU Ruilai;HU Jiapeng;MU Jilin;FU Xingping(College of Ecological and Resources Engineering,Wuyi University,Wuyishan 354300,China;College of Chemistry and Materials Science,Fujian Normal University,Fuzhou 350007,China)

机构地区：[1]武夷学院生态与资源工程学院,武夷山354300 [2]福建师范大学化学与材料学院,福州350007

出　　处：《复合材料学报》2022年第6期2918-2929,共12页Acta Materiae Compositae Sinica

基　　金：福建省自然科学基金(2019J01829,2019J01830,2020J01412,2020J01414);南平市基金(2019J06)。

摘　　要：3D纳米纤维多孔支架作为骨组织工程支架材料具有很好的发展前景。在无其它任何添加剂条件下,通过低温相分离方法制备了左旋聚乳酸-聚己内酯-醋酸纤维素(PCL-CA-PLLA)三维微-纳米复合纤维多孔支架材料。采用SEM分析聚合物比例、淬火时间、聚合物浓度和淬火温度等条件对纤维支架材料形貌影响。PCLCA-PLLA(1∶1∶8)的直径为(276±121)nm,该直径与细胞外基质的尺寸大小(50~500 nm)相当,孔隙率和比表面积分别为95.12%和54.18 m^(2)/g。说明PCL-CA-PLLA三维微-纳米复合纤维多孔支架材料为高孔隙率和大比表面积的三维多孔材料。与纯PLLA纤维支架材料相比,PCL-CA-PLLA三维微-纳米复合纤维多孔支架材料的机械强度有所提高,亲水性有所改善。PCL-CA-PLLA三维微-纳米复合纤维有望成为理想的组织工程支架材料。3D nanofiber scaffold composites in bone tissue engineering are promising.Poly(L-lactic acid)-polycaprolactone-cellulose acetate 3D composite micro-nanofibrous porous scaffolds were prepared by low-temperature phase separation,without the assistance of additives.The effects of PCL-CA-PLLA ratio,quenching time,polymer concentration and quenching temperature on the morphology of fibrous scaffolds were investigated by SEM.The diameter of PCL-CA-PLLA(1∶1∶8)is(276±121)nm,which is similar to the size of the extracellular matrix(50-500 nm),and the porosity and specific surface area are 95.12%and 54.18 m^(2)/g,respectively.It is indicated that PCL-CA-PLLA 3D micro-nanofibrous porous scaffold composites are 3D porous materials with high porosity and large specific surface area.Compared with pure PLLA fibrous scaffolds,the mechanical strength and hydrophilicity of PCL-CA-PLLA 3D micro-nanofibrous porous scaffold composites are improved.PLLA-PCL-CA 3D micronanofibrous are expected to be ideal tissue engineering scaffold materials.

关 键 词：左旋聚乳酸 醋酸纤维素 聚己内酯 微-纳米纤维 支架 生物矿化活性 

分 类 号：TB323.4[一般工业技术—材料科学与工程]