托拉塞米致视野缺失  

Visual field loss caused by torasemide

作　　者：郝杰[1] 原小童 李玉旺[3] 彭芳辰[1] 李元平[1] Hao Jie;Yuan Xiaotong;Li Yuwang;Peng Fangchen;Li Yuanping(Department of Pharmacy,Shanxi Provincial People′s Hospital,Taiyuan 030012,China;Department of Nephrology,Shanxi Provincial People′s Hospital,Taiyuan 030012,China;Department of Prosthodontics,Shanxi Provincial People′s Hospital,Taiyuan 030012,China)

机构地区：[1]山西省人民医院药学部,太原030012 [2]山西省人民医院肾内科,太原030012 [3]山西省人民医院口腔修复科,太原030012

出　　处：《药物不良反应杂志》2022年第6期329-331,共3页Adverse Drug Reactions Journal

摘　　要：1例53岁男性糖尿病肾病Ⅳ期患者因双下肢水肿接受托拉塞米40 mg/d入小壶静脉滴注。用药第3天因利尿效果欠佳遵医嘱将托拉塞米剂量增至80 mg/d。8 h后,患者出现双眼两侧视物遮挡感和视物模糊,眼科检查示双眼视力、眼压正常。考虑为托拉塞米引起的双眼视野缺失,停用该药。2 d后,患者视野缺失症状消失。因病情需要,再次予托拉塞米40 mg/d入小壶静脉滴注治疗6 d,患者未再出现视野缺失。患者的视野改变可能与托拉塞米的剂量较大有关。A 53‑year‑old male patient with stageⅣdiabetic nephropathy received an IV infusion of torasemide 40 mg which was put into a small pot once daily for edema of both lower limbs.On the 3rd day of medication,the dose of torasemide was increased to 80 mg/d according to the doctor′s advice due to poor diuretic effect.Eight hours later,the patient developed bilateral visual occlusion and blurred vision.Ophthalmological examination showed normal visual acuity and intraocular pressure in both eyes.The loss of binocular visual field caused by torasemide was considered.Then the drug was discontinued.After 2 days of drug withdrawal,the patient′s visual field loss disappeared.Because of the patient′s disease condition,IV infusion of torasemide 40 mg which was put into a small pot once daily was given again for 6 days,and the patient did not develop symptoms of visual field loss.The change of visual field might be related to the high dose of torasemide.

关 键 词：磺酰脲化合物 视野 药物相关副作用和不良反应 托拉塞米 

分 类 号：R969[医药卫生—药理学]