Breaking-then-curing strategy for efficient cystic echinococcosis therapy  

作　　者：Tianjiao Zhou Yuan Xu Yuehong Gong Mingtao Yu Enzhen Xu Wusimanjiang Aimaiti Ruijia Ma Lei Xing Hao Wen Jianhua Wang Hulin Jiang 

机构地区：[1]State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China [2]State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Medical University,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China [3]College of Pharmaceutical Sciences,Xinjiang Medical University,Urumqi 830011,China

出　　处：《Chinese Chemical Letters》2022年第6期2949-2953,共5页中国化学快报（英文版）

基　　金：the State Key Laboratory of Pathogenesis,Prevention and Treatment of Central Asia High Incidence Diseases fund(Nos.SKL-HIDCA-2019–7 and SKL-HIDCA2020–1)。

摘　　要：Cystic echinococcosis(CE)is one of the most harmful and life-threatening helminths.As the essential therapeutics,chemotherapy is always difficult to achieve desired anti-echinococcal effect due to the problems that the echinococcus granulosus cyst laminated layer makes the drug difficult to infiltrate and the poor solubility of drugs.In this study,we established a“breaking-then-curing”anti-echinococcal treatment strategy for efficient CE therapy.The photodynamic therapy(PDT)was used as a breaker to produce toxic reactive oxygen species(ROS)and damage the laminated layer of protoscolices(PSCs),leading to enhanced infiltration of albendazole sulfoxide nanoparticles(ABZSO NPs).Then,ABZSO NP was worked as curer for efficient anti-echinococcal treatment.As a result,the breaking-then-curing treatment strategy could generate more intracellular ROS in PSCs induced by plenty of ABZSO NPs,greatly increasing the mortality rate of PSCs in a shorter time than using ABZSO NPs alone,leading to the attenuation of laminated layer and finally disintegrating PSCs.We believe the“breaking-then-curing”strategy will suggest great potential in the treatment of CE and provide a new sight for anti-echinococcal treatment.

关 键 词：Cystic echinococcosis Photodynamic therapy Albendazole sulfoxide PROTOSCOLEX Nanoparticles 

分 类 号：R532.32[医药卫生—内科学]