Novel photoelectrochemical immunosensor for MCF-7 cell detection based on n-p organic semiconductor heterojunction  

作　　者：Qin Zeng Qingya Wei Jiarong Luo Yong Qian Minghui Yang Yingping Zou Limin Lu 

机构地区：[1]Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China [2]Institute of Functional Materials and Agricultural Applied Chemistry,College of Science,Jiangxi Agricultural University,Nanchang 330045,China [3]Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,East China University of Technology,Nanchang 330013,China

出　　处：《Chinese Chemical Letters》2022年第6期2954-2958,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.22174163);the Hunan Provincial Science and Technology Plan Project,China(No.2019TP1001);the Innovation Driven Project of Central South University(No.2020CX002)。

摘　　要：In this work,we developed a novel photoelectrochemical(PEC)sensor based on n-p organic semiconductor heterojunction for sensitive detecting MCF-7 cancer cells.BTA-C4 Ph and PM6 were designed as photoactive materials to form n-p heterojunction,which greatly enhanced the photoelectric conversion efficiency.Antibody-modified magnetic nanoparticles were utilized to capture and separate MCF-7 cells from samples.Detection of MCF-7 is ascribed to the loading of MCF-7 onto BTA-C4 Ph-PM6 modified electrode that resulted in the decrease of photocurrent intensity.The PEC immunosensor displayed a linear concentration ranging from 50 cell/m L to 1×10^(4) cell/m L with a limit of detection(LOD)of 41 cell/m L(S/N=3)for MCF-7.Additionally,the senor also exhibited good stability,excellent selectivity and prominent reproducibility.Furthermore,the sensor was successfully applied to detect MCF-7 in whole blood.This work illustrates that n-p heterojunction of organic semiconductor may find wide applications for the preparation of different photoelectrochemical sensors.

关 键 词：Photoelectrochemical immunosensor Organic semiconductors n-p Heterojunction MCF-7 

分 类 号：O657.1[理学—分析化学] TP212.2[理学—化学] R318.6[自动化与计算机技术—检测技术与自动化装置]