Copper-catalyzed diversified annulations betweenα-diketones and alkynylα-diketones  

作　　者：Xiangwen Kong Fang Yu Shengtong Niu Fan Gong Shuang Yang Jinggong Liu Benlong Luo Xinqiang Fang 

机构地区：[1]State Key Laboratory of Structural Chemistry,and Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Center for Excellence in Molecular Synthesis,Fujian Institute of Research on the Structure of Matter,University of Chinese Academy of Sciences,Fuzhou 350100,China [2]Pingxiang University,Pingxiang 337055,China [3]Orthopedics Department,Guangdong Provincial Hospital of Traditional Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China

出　　处：《Chinese Chemical Letters》2022年第6期2997-3002,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22071242 and 21871260);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000);Fujian Natural Science Foundation(No.2018J05035);Science and Technology Research Program of the Education Department of Jiangxi Province(No.GJJ1991151)。

摘　　要：Copper-catalyzed divergent annulations betweenα-diketones and alkynylα-diketones have been achieved,delivering a series of highly functionalized and biologically important cis-hexahydro-2Hcyclopenta[b]furan(HCPF)and 2-hydroxydihydrofuran-3(2H)-one(HDFO)products with high levels of stereoselectivity under identical conditions.The protocol features the use of earth-abundant copper catalyst,mild conditions,shortening synthetic routes in constructing different molecular frameworks,and reducing the corresponding possible waste production.The substituents of the nucleophilicα-diketones play crucial roles in switching the reaction pathways.

关 键 词：Copper catalysis α-Diketones Diversified annulations Substituents-controlled reactivities Atom economy 

分 类 号：O626.11[理学—有机化学]