microRNA在主动脉瘤中的研究进展  

The advances of microRNA in aortic aneurysms

作　　者：罗聪聪 钟永亮[1] 罗程 郭如韬 葛翼鹏[1] 朱俊明[1] Luo Congcong;Zhong Yongliang;Luo Cheng;Guo Rutao;Ge Yipeng;Zhu Junming(Department of Cardiovascular Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院心血管外科,北京100029

出　　处：《中华胸心血管外科杂志》2022年第6期371-375,共5页Chinese Journal of Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(81970393)。

摘　　要：主动脉瘤是一种主动脉呈慢性扩张的疾病,通常无症状,一旦破裂病死率极高,目前尚无有效治疗药物。microRNA特指19~25核苷酸的非编码小RNA。microRNA靶向多个基因的特性使其形成了复杂的调控网络而受到研究者的关注。越来越多研究表明microRNA与主动脉瘤的发生发展关系密切。众多microRNA参与了主动脉瘤复杂的病理机制过程,包括内皮细胞功能失调、炎性细胞浸润、平滑肌细胞凋亡、细胞外基质降解等。本文将阐述用于主动脉瘤研究的动物模型以及microRNA与主动脉瘤的最新研究进展。Aortic aneurysm(AA)is a vascular disease involving the progressive dilation of aorta diameter.It is usually asymptomatic but with high mortality once rupture.Currently,there is no effective pharmacologic treatment.MicroRNA specifically refers to non-coding small RNAs consisting of 19-25 nucleotides.The characteristic of microRNA targeting multiple genes seems to form a complicated regulation network,which receives considerable attention.Emerging studies show that microRNAs are closely related to the occurrence and development of AA.Many microRNAs are involved in multiple cell processes and functions and may participate in the pathogenesis of AA,including endothelial cell dysfunction,inflammatory cell infiltration,smooth muscle cell apoptosis,and extracellular matrix degradation.This article will describe the animal models for AA research and the latest progression of microRNA and AA.

关 键 词：主动脉瘤 有效治疗药物 非编码小RNA 炎性细胞浸润 细胞外基质降解 无症状 动物模型 MICRORNA 

分 类 号：R543.16[医药卫生—心血管疾病]