Alterations in microbiota of patients with COVID-19:potential mechanisms and therapeutic interventions  

作　　者：Bin Wang Lei Zhang Yongqiang Wang Tong Dai Ziran Qin Fangfang Zhou Long Zhang 

机构地区：[1]MOE Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,310058 Hangzhou,PR China [2]Department of Orthopaedic Surgery,The First Affiliated Hospital of Wenzhou Medical University,325000 Wenzhou,PR China [3]Institutes of Biology and Medical Science,Soochow University,325200 Suzhou,PR China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1597-1611,共15页信号转导与靶向治疗（英文）

基　　金：We would like to apologize to those researchers whose related work we were not able to cite in this review.This work was supported by a special program from the Ministry of Science and Technology of China(2021YFA101000);the Chinese National Natural Science Funds(U20A20393,U20A201376,31925013,3212500161,82041009,31871405,31701234,81902947,82041009,31671457,31571460,and 91753139);Jiangsu Provincial Distinguished Young Scholars award(BK20180043);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);Zhejiang Provincial Natural Science Foundation of China(LBY21H060001 and LGF19H180007);Zhejiang Provincial Medical and Health Science and Technology Program(2020RC115);A project Funded by the Priority Acadamic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX17_2036).

摘　　要：The global coronavirus disease 2019(COVID-19)pandemic is currently ongoing.It is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea,nausea,or vomiting.Moreover,the respiratory and gastrointestinal tracts are the primary habitats of human microbiota and targets for SARS-CoV-2 infection as they express angiotensin-converting enzyme-2(ACE2)and transmembrane protease serine 2(TMPRSS2)at high levels.There is accumulating evidence that the microbiota are significantly altered in patients with COVID-19 and post-acute COVID-19 syndrome(PACS).

关 键 词：PATIENTS ACUTE RESPIRATORY 

分 类 号：R563.1[医药卫生—呼吸系统]