Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques  

作　　者：Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin 

机构地区：[1]Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases,NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing 100021,China [2]National Center of Technology Innovation for Animal Model,Beijing,China [3]CAS Key Laboratory of Infection and Immunity,National Laboratory of Macromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [4]Department of Radiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1746-1755,共10页信号转导与靶向治疗（英文）

基　　金：ACKNOWLEDGEMENTS We thank Sinovac Biotech Ltd for providing the inactivated vaccines as a gift for these prospective studies.This work was supported by the National Research and Development Project of China(Grant Nos.2021YFC0863300,2020YFA0707500,2018YFA0900801);the CAMS Initiative for Innovative Medicine of China(Grant No.2021-I2M-1-035);the Strategic Priority Research Program(XDB29010000,XDB37030000),CAS(YSBR-010);the Special Funds of the National Natural Science Foundation of China(Grant Nos.82061138007 and 92169210);Xiangxi Wang was supported by the Ten Thousand Talent Program and the NSFS Innovative Research Group(No.81921005).

摘　　要：Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type.

关 键 词：NEUTRAL HARBOR OMI 

分 类 号：R373[医药卫生—病原生物学]