Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events  

作　　者：Junxian Ou Wendong Lan Xiaowei Wu Tie Zhao Biyan Duan Peipei Yang Yi Ren Lulu Quan Wei Zhao Donald Seto James Chodosh Zhen Luo Jianguo Wu Qiwei Zhang 

机构地区：[1]Guangdong Provincial Key Laboratory of Virology,Institute of Medical Microbiology,Jinan University,510632 Guangzhou,China [2]BSL-3 Laboratory(Guangdong),Guangdong Provincial Key Laboratory of Tropical Disease Research,School of Public Health,Southern Medical University,510515 Guangzhou,China [3]Bioinformatics and Computational Biology Program,School of Systems Biology,George Mason University,Manassas,VA 20110,USA [4]Department of Ophthalmology,Howe Laboratory Massachusetts Eye and Ear,Harvard Medical School,Boston,MA 02114,USA [5]Foshan Institute of Medical Microbiology,528315 Foshan,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1808-1816,共9页信号转导与靶向治疗（英文）

基　　金：We gratefully acknowledge the authors,originating and submitting laboratories of the sequences from GISAID’s EpiCoV™Database that this study used.This work was supported by grants from the National Key Research and Development Program of China(2018YFE0204503);National Natural Science Foundation of China(32170139 and 81730061);Natural Science Foundation of Guangdong Province(2018B030312010,2021A1515010788,and 2022A1515011190);the Fundamental Research Funds for the Central Universities(21622101);Guangdong Science and Technology Program key projects(2021B1212030014).

摘　　要：The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.Ongoing concerns of emergent variants include possible recombinants,as genome recombination is an important evolutionary mechanism for the emergence and re-emergence of human viral pathogens.In this study,we identified diverse recombination events between two Omicron major subvariants(BA.1 and BA.2)and other variants of concern(VOCs)and variants of interest(VOIs),suggesting that co-infection and subsequent genome recombination play important roles in the ongoing evolution of SARS-CoV-2.Through scanning high-quality completed Omicron spike gene sequences.

关 键 词：subsequent diverse recombination 

分 类 号：R373[医药卫生—病原生物学]