Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination  

作　　者：Xiangyang Chi Yingying Guo Guanying Zhang Hancong Sun Jun Zhang Min Li Zhengshan Chen Jin Han Yuanyuan Zhang Xinghai Zhang Pengfei Fan Zhe Zhang Busen Wang Xiaodong Zai Xuelian Han Meng Hao Ting Fang Jinghan Xu Shipo Wu Yi Chen Yingying Fang Yunzhu Dong Bingjie Sun Jinlong Zhang Jianmin Li Guangyu Zhao Changming Yu Qiang Zhou Wei Chen 

机构地区：[1]Institute of Biotechnology,Academy of Military Medical Sciences,Beijing 100071,China [2]Center for Infectious Disease Research,Westlake Laboratory of Life Sciences and Biomedicine,Key Laboratory of Structural Biology of Zhejiang Province,Institute of Biology,Westlake Institute for Advanced Study,School of Life Sciences,Westlake University,Hangzhou 310024 Zhejiang Province,China [3]State Key Laboratory of Pathogen and Biosecurity,Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China [4]Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,Hubei 430071,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1831-1841,共11页信号转导与靶向治疗（英文）

基　　金：We thank the cryo-EM facility and the High-Performance Computing Center of Westlake University for providing technical support.We thank the Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,China,for providing the SARS-CoV-2.This research was supported by grants from the National Natural Science Foundation of China(projects 32022037,81803429);the Young Elite Scientists Sponsorship Program by CAST,the Leading Innovative and Entrepreneur Team Introduction Program of Hangzhou,the Special Research Program of Novel Coronavirus Pneumonia of Westlake University and Tencent Foundation.

摘　　要：The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by infection-and vaccination-induced antibodies,highlighting the demands for research on the continuing discovery of broadly neutralizing antibodies(bnAbs).Here,we developed a panel of bnAbs against Omicron and other variants of concern(VOCs)elicited by vaccination of adenovirus-vectored COVID-19 vaccine(Ad5-nCoV).

关 键 词：NEUTRAL VACCINATION OMI 

分 类 号：R186[医药卫生—流行病学] R563.1[医药卫生—公共卫生与预防医学]