细胞外囊泡在人巨细胞病毒感染中的作用  

The role of extracellular vesicles in human cytomegalovirus infection

作　　者：李华美[1] 何林 陶然[1] 尚世强[1] Huamei Li;Lin He;Ran Tao;Shiqiang Shang(Department of Clinical Laboratory,the Children′s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,National Children′s Regional Medical Center,Hangzhou 310000,China;Zhejiang University School of Medicine,Clinical Medicine(Pediatrics),MD(Class of 2020),Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属儿童医院实验检验中心,国家儿童健康与疾病临床医学研究中心,国家儿童区域医疗中心,杭州310000 [2]浙江大学医学院临床医学(儿科学)2020级,杭州310000

出　　处：《中华检验医学杂志》2022年第6期656-660,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81971422);浙江省分析测试基金(LGC19H200006)。

摘　　要：细胞外囊泡(EV)是包含蛋白质、脂质、核酸的膜结构囊泡。病毒感染细胞产生的EV, 参与感染细胞和未感染细胞之间的通讯。人巨细胞病毒(HCMV)感染细胞产生的EV通过胞间传递, 既可促进HCMV的传播和感染、逃避宿主免疫应答, 又可激活机体免疫应答抗HCMV感染。深入研究HCMV感染细胞产生EV的机制及其成分变化, 将为HCMV感染的诊断和防治提供新思路。目前相关研究已取得一些成果, 但还不够深入。未来EV分离和鉴定技术的进步及经济成本的降低将有助于研究的广泛开展和应用。Extracellular vesicles(EV)are membrane structured vesicles containing proteins,lipids and nucleic acids.EVS produced by virus-infected cells are involved in communication between infected and uninfected cells.EV produced by human cytomegalovirus(HCMV)infected cells can promote the transmission and infection of HCMV and escape the host immune response.It can also activate the body′s immune response against HCMV infection.In-depth study of the mechanism and compositional changes of EV produced by HCMV infected cells will contribute to the prevention,diagnosis,and treatment of HCMV.The current research has achieved some results,but they are not deep enough.Future advancements in EV isolation and identification technologies and the reduction of economic costs will contribute to the extensive development and clinical application of the research.

关 键 词：巨细胞病毒 细胞外囊泡 感染 

分 类 号：R511[医药卫生—内科学]