血吸虫虫卵抗原诱导免疫细胞的机制及其作用  

The mechanism and function of Schistosoma egg antigens in regulating immune cells

作　　者：邹冬雪 肖建华[1] ZOU Dong-xue;XIAO Jian-hua(Institute of Pathogenic Biology,University of South China,Hengyang 421001,Hunan Province,China)

机构地区：[1]南华大学病原生物学研究所,湖南衡阳421001

出　　处：《微生物学免疫学进展》2022年第3期77-81,共5页Progress In Microbiology and Immunology

基　　金：国家自然科学基金(81101274)。

摘　　要：血吸虫病主要由虫卵沉积于肝肠组织引起免疫病理性疾病。虫卵的分泌物和排泄物都可以作为抗原物质,通过多种机制刺激巨噬细胞、树突状细胞、中性粒细胞、T细胞和调节性B细胞(regulatory B cell,Breg细胞)等分泌细胞因子和趋化因子,从而刺激宿主的免疫应答,影响虫卵肉芽肿和纤维化的发生、发展。有些虫卵抗原可以诱导M2型巨噬细胞、2型辅助性T细胞(type 2 helper T cell,Th2细胞)、调节性T细胞(regulatory T cell,Treg细胞)和Breg细胞的分化,可以用于某些炎症疾病和免疫疾病的治疗。现主要对虫卵抗原诱导免疫细胞的机制和作用作一概述。Schistosomiasis is mainly caused by the deposition of Schistosoma eggs in the liver and intestine tissues to trigger immunopathological diseases.The secretions and excrements of eggs can be used as antigens to stimulate macrophages,dendritic cells,neutrophils,T cells and Breg cells secrete cytokines and chemokines through various mechanisms,thereby regulating the host’s immune response and affecting the occurrence and development of egg granuloma and fibrosis.Some egg antigens can induce the differentiation of M2 type macrophages and Th2,Treg and Breg cells,and can be used for the treatment of certain inflammatory diseases and immune diseases.This article mainly reviews the mechanism and role of egg antigens in regulating immune cells.

关 键 词：血吸虫 虫卵抗原 免疫细胞 疾病治疗 

分 类 号：R383.24[医药卫生—医学寄生虫学]