腹股沟斜疝修补术患儿应用布洛芬注射液的镇痛效果研究  

Analgesic Effect of Ibuprofen Injection in Children Undergoing Indirect Inguinal Hernia Repair

作　　者：彭凡岭 刘付玉 阚景祥 张一博 PENG Fanling;LIU Fuyu;KAN Jingxiang;ZHAGN Yibo(Department of Outpatient operating room,Junan County People’s Hospital,Linyi 276600,Shandong,China;Department of Anesthesiology,Linyi People’s Hospital,Linyi 273300,Shandong,China;Department of Anesthesiology,Pingyi County Medical Hospital,Linyi 273300,Shandong,China)

机构地区：[1]莒南县人民医院门诊手术室,山东临沂276600 [2]临沂市人民医院麻醉科,山东临沂273300 [3]平邑县中医院麻醉科,山东临沂273300

出　　处：《中国药物滥用防治杂志》2022年第6期754-757,766,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：临沂市2019年科技创新发展计划(编号:201920052)。

摘　　要：目的:探讨腹股沟斜疝修补术患儿应用布洛芬注射液镇痛的效果。方法:选取2020年1月—2021年12月在我院进行腹股沟斜疝修补术的患儿132例作为研究对象,按照随机数字表法分为布洛芬注射液组、布洛芬栓组与对照组,每组44例。在开始维持麻醉时,布洛芬注射液组开辟另外一个静脉通路,静脉滴注10 mg/kg的布洛芬,布洛芬栓组给予5 mg/kg布洛芬塞肛,对照组给予静脉滴注10 mg/kg的生理盐水。所有患儿在首次用药4 h后再次给药1次。比较三组术后不同时间点疼痛情况、儿童疼痛行为量表评分及不良反应发生情况。结果:布洛芬注射液组术后0~1 h、1~2 h疼痛比例低于布洛芬栓组及对照组,布洛芬注射液组及布洛芬栓组2~4 h疼痛比例低于对照组,差异有统计学意义(P<0.05);布洛芬注射液组、布洛芬栓组不同时间点儿童疼痛行为量表评分低于对照组,且布洛芬注射液组低于布洛芬栓组,差异有统计学意义(P<0.05);布洛芬注射液组、布洛芬栓组舒芬太尼补充量低于对照组,且布洛芬注射液组低于布洛芬栓组,差异有统计学意义(P<0.05);三组瑞芬太尼补充量、丙泊酚补充量及术后苏醒时间比较,差异无统计学意义(P>0.05);布洛芬注射液组、布洛芬栓组与对照组不良反应发生比较[3例(6.82%)vs 2例(4.55%)vs 1例(2.27%)],差异无统计学意义(P>0.05)。结论:布洛芬注射剂给药与布洛芬栓给药可降低腹腔镜下腹股沟斜疝修补术患儿术后疼痛程度,能够有效辅助降低阿片类药物术后患儿镇痛,而布洛芬注射剂给药较布洛芬栓剂给药效果更好。Objective:To evaluate the analgesic effect of ibuprofen injection in children undergoing laparoscopic indirect inguinal hernia repair.Methods:A total of 132 children who underwent laparoscopic indirect inguinal hernia repair in our hospital from January 2020 to December 2021 were included.The children were randomly divided into control group,ibuprofen suppository group and ibuprofen injection group,with 44 children in each group.At the beginning of maintenance anesthesia,ibuprofen injection group opened up another venous pathway,intravenous drip of 10 mg/kg ibuprofen,ibuprofen suppository group was given 5 mg/kg ibuprofen to plug the anus,and the control group was given intravenous drip of 10mg/kg normal saline.All children were administered once again 4 hours after the first administration.The scores of postoperative children’s pain behavior scale and the proportion of children with pain in ibuprofen injection group,ibuprofen suppository group and control group were compared.The postoperative analgesic supplementation and recovery time of the three groups were compared.The incidence rate of adverse drug reactions in 3 groups was compared.Results:The pain ratio of ibuprofen injection group at 0-1 and 1-2 h after operation was lower than that of ibuprofen suppository group and control group,and the pain ratio of ibuprofen injection group and ibuprofen suppository group at 2-4 h was lower than that of control group(P<0.05).The proportion of pain in ibuprofen injection group and ibuprofen suppository group for 2-4 hours was lower than that in the control group,the difference was statistically significant(P<0.05).The scores of children’s pain behavior scale in ibuprofen injection group and ibuprofen suppository group at different time points were lower than those in the control group,and the ibuprofen injection group was lower than that in ibuprofen suppository group,the difference was statistically significant(P<0.05).The supplement amount of sufentanil in ibuprofen injection group and ibuprofen suppository grou

关 键 词：手术 患儿 布洛芬 镇痛 

分 类 号：R726.1[医药卫生—儿科]