干扰素应用于宫颈病变患者术后的效果研究  

Effect of Interferon on Postoperative Patients with Cervical Lesions

作　　者：郭睿[1] 李梅[1] 张苗苗[1] 张凡[1] GUO Rui;LI Mei;ZHANG Miaomiao;ZHANG Fan(Department of Gynecology and Obstetrics,Beijing Chuiyangliu Hospital,Beijing 100022,China)

机构地区：[1]北京市垂杨柳医院妇产科,北京100022

出　　处：《中国药物滥用防治杂志》2022年第6期780-784,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：北京市朝阳区科技计划(编号:CYSF181203)。

摘　　要：目的:分析干扰素应用于宫颈病变患者术后的效果。方法:选取2020年2月—2021年2月本院收治的100例宫颈病变患者作为研究对象,分为单独高频电波刀手术治疗组(对照组)、高频电波刀手术联合重组人干扰素α-2a治疗组(观察组),每组50例。比较两组临床疗效、阴道出血量、阴道排液量、恢复情况、炎症指标、并发症发生情况。结果:观察组总有效率为94.00%,高于对照组的78.00%(P<0.05);观察组阴道出血量少于对照组,阴道排液量≤月经量比例高于对照组,>月经量比例低于对照组(P<0.05);观察组愈合时间、自觉不适感消失时间、非典型增生症状消失时间、阴道分泌物恢复正常时间均短于对照组(P<0.05);观察组血浆ET-1、IL-1β、IL-6、hs-CRP、TNF-α、S100β蛋白水平均低于对照组(P<0.05);观察组并发症发生率为8.00%,低于对照组的26.00%(P<0.05)。结论:联合干扰素治疗宫颈病变的效果确切,可减轻炎症反应,促进患者恢复,降低并发症发生概率。Objective:To analyze the effect of interferon on postoperative patients with cervical lesions.Methods:A total of 100 patients with cervical lesions admitted to our hospital from February 2020 to February 2021 were selected as the study subjects.They were divided into single high frequency radio knife treatment group(control group)and high frequency radio knife treatment combined with recombinant human interferonα-2a treatment group(observation group),50 cases in each group.The clinical efficacy,vaginal bleeding volume,vaginal discharge,recovery,inflammatory indicators and complications were compared between the two groups.Results:The total effective rate of the observation group was 94.00%,which was higher than 78.00%of the control group(P<0.05).The amount of vaginal bleeding in the observation group was less than that in the control group,the proportion of vaginal discharge≤menstrual volume was higher than that in the control group,and the proportion of vaginal discharge>menstrual volume was lower than that in the control group(P<0.05).The healing time,disappearance time of conscious discomfort,disappearance time of atypical hyperplasia symptoms and recovery time of vaginal secretion in the observation group were shorter than those in the control group(P<0.05).Plasma ET-1,IL-1β,IL-6,hs-CRP,TNF-αand S100βprotein levels in the observation group were lower than those in the control group(P<0.05).The incidence of complications in the observation group was 8.00%,which was lower than 26.00%in the control group(P<0.05).Conclusion:The effect of combined interferon in the treatment of cervical lesions is exact,which can reduce the inflammatory response,promote the recovery of patients and reduce the incidence of complications.

关 键 词：宫颈病变 药物治疗 干扰素 高频电波刀 炎症因子 

分 类 号：R713.4[医药卫生—妇产科学]