七氟醚复合丙泊酚对冠状动脉粥样硬化性心脏病的疗效  

Efficacy of Sevoflurane Combined with Propofol for Coronary Atherosclerotic Heart Disease

作　　者：田书宁 蒙臣 罗向红[2,3] 王贤裕[2,3] Tian Shu-ning;Meng Chen;Luo Xiang-hong;Wang Xian-yu(Jinzhou Medical University Shiyan Taihe Hospital Graduate Training Base(Affiliated Hospital of Hubei University of Medicine),Shiyan 442000,Hubei Province,China;Department of Anesthesiology,Taihe Hospital,Shiyan 442000,Hubei Province,China;Institute of Anesthesiology,Hubei University of Medicine,Shiyan 442000,Hubei Province,China)

机构地区：[1]锦州医科大学十堰市太和医院研究生培养基地(湖北医药学院附属医院),湖北十堰442000 [2]十堰市太和医院麻醉科,湖北十堰442000 [3]湖北医药学院麻醉学研究所,湖北十堰442000

出　　处：《中国社区医师》2022年第18期46-48,共3页Chinese Community Doctors

基　　金：国家重点研发计划(编号:2018YFC2001904);湖北省卫生健康委科研项目(编号:WJ2019M058)。

摘　　要：目的:探讨冠状动脉粥样硬化性心脏病患者实施七氟醚复合丙泊酚麻醉的临床疗效。方法:选取2019年10月-2021年3月收治的90例冠状动脉粥样硬化性心脏病患者,将其按照数字随机表法予以分组,每组45例。对照组实施丙泊酚麻醉,研究组实施七氟醚复合丙泊酚麻醉,对比分析两组临床效果。结果:麻醉后,两组患者平均动脉压、心率均低于麻醉前,而研究组高于对照组,差异有统计学意义(P<0.05)。手术后,两组患者肌钙蛋白I、肌酸激酶同工酶均高于手术前,观察组低于对照组,差异有统计学意义(P<0.05)。手术后,两组中心静脉压高于手术前,左心射血分数低于手术前,而研究组中心静脉压低于对照组,左心射血分数高于对照组,差异有统计学意义(P<0.05)。结论:对于冠状动脉粥样硬化性心脏病患者,七氟醚复合丙泊酚麻醉可减轻对生命体征的影响,同时也减轻对心肌功能及心功能产生的损伤。Objective:To explore the clinical efficacy of sevoflurane combined with propofol anesthesia in patients with coronary atherosclerotic heart disease.Methods:From October 2019 to March 2021,90 patients with coronary atherosclerotic heart disease were selected and randomly divided into two groups,with 45 cases in each group.The control group was given propofol anesthesia,and the study group was given sevoflurane combined with propofol anesthesia.Clinical effect in two groups was compared and analyzed.Results:After anesthesia,the mean arterial pressure and heart rate of patients in the two groups were lower than those before anesthesia,while the study group was higher than the control group,with statistically significant difference(P<0.05).The troponin I and creatine kinase isoenzyme of the two groups after operation were higher than those before operation,while the study group was lower than the control group,with statistically significant difference(P<0.05).The central venous pressure of the two groups after operation was higher than that before operation,left heart ejection fraction was lower than that before operation,while central venous pressure of study group was lower than that of control group,left heart ejection fraction of study group was higher than that of control group,with statistically significant difference(P<0.05).Conclusion:For patients with coronary atherosclerotic heart disease,sevoflurane combined with propofol anesthesia can reduce the impact on vital signs,but also reduce the damage to myocardial function and cardiac function.

关 键 词：七氟醚 丙泊酚 冠状动脉粥样硬化性心脏病 

分 类 号：R614[医药卫生—麻醉学]