接种两种疫苗偶合肾病综合征1例调查  

Investigation on A Case of Nephrotic Syndrome Coupled to Two Vaccines

作　　者：陈凤华 于民[2] 马敬仓[2] 刘景顺[2] 徐凌忠[3] Chen Feng-hua;Yu Min;Ma Jing-cang;Liu Jing-shun;Xu Ling-zhong(Health Comprehensive Law Enforcement Brigade of Mudan District,Heze 274000,Shandong Province,China;Heze Center for Disease Control and Prevention,Heze 274000,Shandong;Province,China School of Public Health,Shandong University,Jinan 250014,Shandong Province,China)

机构地区：[1]菏泽市牡丹区卫生健康综合执法大队,山东菏泽274000 [2]菏泽市疾病预防控制中心,山东菏泽274010 [3]山东大学公共卫生学院,山东济南250014

出　　处：《中国社区医师》2022年第19期154-156,共3页Chinese Community Doctors

基　　金：国家自然科学基金委员会面上项目(项目编号71673169)。

摘　　要：目的:调查某肾病综合征病例发病是否为注射疫苗所引起。方法:对病例开展个案调查,收集生产企业、接种方、受种方相关资料;组成市级预防接种异常反应调查诊断专家组开展调查诊断,作出诊断意见。结果:接种方儿童2020年9月18日约10:00接种无细胞百白破联合疫苗和麻腮风联合减毒活疫苗,观察30 min后无异常。先后在2所医院住院治疗,主要诊断为原发性肾病综合征。疫苗质量合格,疫苗接种符合技术标准和规程。市级AEFI调查诊断意见为不属于预防接种异常反应。结论:受种方儿童接种疫苗后发生的肾病综合征与疫苗接种无关,属于AEFI偶合症。Objective:To investigate whether a case of nephrotic syndrome was caused by injection of vaccine.Methods:The case investigation was carried out to collect relevant information of manufacturers,vaccinator and recipient;A municipal expert panel on adverse events following immunization was formed to conduct an investigation and give a diagnosis opinion.Results:The child was inoculated with acellular DTP combined vaccine and MMR combined live attenuated vaccine at 10:00 on September 18,2020,and no abnormality was observed within 30 minutes.The case was hospitalized successively in two hospitals with primary diagnosis of nephrotic syndrome.The vaccines were qualified,the vaccination was compliant with the technical standards and procedures.Diagnosis opinion by the municipal expert panel on adverse events following immunization was that it was not abnormal reaction of vaccination.Conclusion:The nephrotic syndrome of children after vaccination is not related to vaccination and it is coupled to AEFI.

关 键 词：肾病综合征 疫苗 预防接种 偶合 儿童 

分 类 号：R599[医药卫生—内科学]