绝经激素治疗对40~65岁女性绝经综合征改善的回顾性队列研究  

A retrospective cohort study on menopause hormone therapy:menopause syndrome improvement in women aged 40 to 65 years

作　　者：宋子程 李长滨[1] 郑燕伟[1] 黄文俊 陶敏芳[1] Song Zicheng;Li Changbin;Zheng Yanwei;Huang Wenjun;Tao Minfang(Department of Obstetrics and Gynecology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院妇产科,上海200233

出　　处：《中华生殖与避孕杂志》2022年第3期283-286,共4页Chinese Journal of Reproduction and Contraception

摘　　要：目的探讨绝经激素治疗对40~65岁女性绝经综合征与生活质量的改善情况。方法回顾性队列研究分析2010年4月至2019年11月期间就诊于上海交通大学附属第六人民医院妇产科更年期门诊40~65岁患者的临床资料,采用绝经期评分表(menopause rating scale,MRS)评价患者的绝经综合征及其严重程度的影响。评估时间分别为绝经激素治疗前以及治疗后3、6、12个月。结果在接受绝经激素治疗前以及治疗后3、6、12个月,患者MRS总分分别为9.25、5.25、4.67和4.25。与基线水平比较,绝经激素治疗后患者MRS总分显著下降(均P<0.001)。此外,治疗后,50~54岁组MRS分值下降幅度显著高于40~44岁组(P=0.043),而研究对象的其他特征,如婚姻、收入、体质量指数等,与MRS分值下降无关(均P>0.05)。结论绝经激素治疗能够显著改善40~65岁女性的绝经综合征,其中对于50~54岁组效果优于40~44岁组。Objective To investigate the impact of menopause hormone therapy(MHT)on life quality improvement in women aged 40-65 years who suffered from menopausal syndrome.Methods A retrospective cohort study was performed to analyze the clinical data of patients aged 40-65 years attending the menopause clinic of the Department of Obstetrics and Gynecology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,between April 2010 and November 2019.The menopause rating scale(MRS)was implemented to evaluate the scale and severity of menopausal syndrome.Results The total MRS scores were 9.25,5.25,4.67 and 4.25 before and 3,6 and 12 months after menopausal hormone therapy,respectively.Compared with baseline,MRS score decreased significantly after menopausal hormone therapy(all P<0.001).Furthermore,After treatment,the decrease of MRS score in 50-54 years old group was significantly higher than that in 40-44 years old group(P=0.043).Other characteristics such as marriage,income and body mass index,were not associated with the decrease of MRS score(all P>0.05).Conclusion MHT can significantly improve menopausal syndrome in women aged 40 to 65 years,and the effect in 50-54 years old group is better than that in 40-44 years old group.

关 键 词：绝经激素治疗 绝经 年龄分布 生活质量 

分 类 号：R711.75[医药卫生—妇产科学]