长链非编码RNA在多囊卵巢综合征中的作用及分子机制  

Roles and molecular mechanisms of long non-coding RNA in polycystic ovary syndrome

作　　者：孙哲[1] 孙贇[1] Sun Zhe;Sun Yun(Center for Reproductive Medicine,Renji Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai 200135,China)

机构地区：[1]上海交通大学医学院附属仁济医院生殖医学中心,上海市辅助生殖与优生重点实验室,上海200135

出　　处：《中华生殖与避孕杂志》2022年第3期306-310,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金面上项目(81771648);上海市地方高校创新研究团队(SSMU-ZLCX20180401);上海市教育委员会高峰高原学科建设计划(20161413)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种累及5%~20%育龄妇女的生殖内分泌和代谢紊乱性疾病,是导致无排卵性不孕的主要原因。PCOS的临床表现具有明显的复杂性和异质性,其发病机制尚未明确。长链非编码RNA(long non-coding RNA,lncRNA)是转录长度大于200个核苷酸的非编码RNA,能通过表观修饰、转录、转录后三个水平调控细胞生长、增殖、分化、凋亡等许多生物学过程。lncRNA是近年来PCOS领域的研究热点,研究显示PCOS患者的外周血、卵巢颗粒细胞、卵泡液、子宫内膜中的lncRNA水平与正常女性存在显著差异,且与PCOS排卵障碍、高雄激素血症、胰岛素抵抗、子宫内膜容受性等密切相关,提示lncRNA是PCOS发病机制的重要部分,可能成为PCOS诊断的分子标志物。本文就lncRNA在PCOS中的作用及其分子机制进行综述。Polycystic ovary syndrome(PCOS)is a common reproductive endocrinopathy and metabolic disorder affecting 5%-20%of reproductive aged women and is the leading cause of anovulatory infertility.PCOS is highly complex and heterogeneous and the pathogenetic mechanism of it is yet unclear.Long non-coding RNA(lncRNA)are transcripts of more than 200 nucleotides which lack defined protein coding potential.LncRNA regulate cell growth,proliferation,differentiation,apoptosis in epigenetics,transcription and post-transcription levels.Recent studies indicated that lncRNA are dysregulated in blood,ovary granulosa cells,follicle fluid and uterine endometrium of PCOS patients.LncRNA are involved in anovulation,hyperandrogenism,insulin resistance and endometrial receptivity in PCOS and play pivotal roles in elucidating the pathogenesis of PCOS and providing potential biomarkers.In this review,we focused on roles and molecular mechanisms of lncRNA in PCOS.

关 键 词：多囊卵巢综合征 长链非编码RNA 排卵障碍 高雄激素血症 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]