子宫内膜异位症啮齿类动物模型建立的新进展  

Update on development of rodent models for endometriosis

作　　者：阮静瑶 易晓芳[1] Ruan Jingyao;Yi Xiaofang(Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中华生殖与避孕杂志》2022年第3期324-327,共4页Chinese Journal of Reproduction and Contraception

摘　　要：子宫内膜异位症是一种最常见的影响育龄女性健康的慢性疾病,至今其病因与发病机制仍不清楚,构建适宜的动物模型有利于推进相关基础研究。目前啮齿类动物是较为经济,易于饲养,且子宫内膜结构与人类相似的实验对象。本文旨在分析比较近四年来啮齿类动物子宫内膜自体移植模型、同种异体移植模型以及异种移植模型等的构建方法、影响造模成功率的因素及其优缺点,并介绍了荧光定位模型、疼痛模型、深部型子宫内膜异位症模型等进展,为研究者进行关于发病机制和治疗的体内研究时选择适宜的动物模型提供参考。Endometriosis is one of the most common chronic diseases affecting the health of women of reproductive age,etiology and pathogenesis of which are still unclear.Therefore,the establishment of an appropriate animal model is imperative to the promotion of relevant basic research.Rodents are relatively economical,easy to feed,and have similar endometrial structure to humans.The objective of this paper is to compare the advantages and disadvantages among different autologous,homologous and xenotransplanted rodent models on experimental endometriosis in recent four years and factors influencing the success rate of modeling.The utility of models on fluorescent localization models,deep endometriosis and pain-related studies is also elaborated,so as to facilitate the selection of animal models for subsequent in vivo studies on pathogenesis and therapeutic strategies in endometriosis.

关 键 词：子宫内膜异位症 实验动物模型 啮齿目 

分 类 号：R711.71[医药卫生—妇产科学] R-332[医药卫生—临床医学]