糖尿病家族史和三高聚集与糖尿病患病的关系  

Associations between family diabetes history and clustered risk factors with diabetes

作　　者：徐红[1] 倪倬健 黄玮奕[3] XU Hong;NI Zhuo-jian;HUANG Wei-yi(不详;Department of Health Education and Chronic Disease Control,Nantong Center for Disease Control and Prevention,Nantong,Jiangsu 226007,China)

机构地区：[1]南通市疾病预防控制中心健康教育与慢病防制科,江苏226007 [2]南通市海门区疾病预防控制中心慢病防制科 [3]南通市疾病预防控制中心办公室

出　　处：《现代预防医学》2022年第13期2470-2475,共6页Modern Preventive Medicine

摘　　要：目的了解糖尿病家族史和三高聚集与糖尿病患病的关系,为制定适宜的糖尿病防治策略提供参考依据。方法2019年10月至2020年4月采用多阶段随机抽样的方法,在江苏省南通市海门区随机抽取8981名18周岁以上常住居民,进行问卷调查和体格检查,采用t检验、χ;检验、多因素非条件logistic回归研究糖尿病家族史和三高聚集对糖尿病患病的影响。结果江苏省南通市海门区18周岁以上常住居民最终纳入8350名,糖尿病患病率11.2%,标化患病率5.4%。在调整了性别、年龄、文化程度、职业、总静态时间等混杂因素后,多因素非条件logistic回归分析结果显示,有糖尿病家族史者糖尿病患病风险是无家族史者的3.43倍(OR=3.43,95%CI=2.86~4.11),超重肥胖者糖尿病患病风险是非超重肥胖者的1.60倍(OR=1.60,95%CI=1.39~1.83),高三酰甘油血症者糖尿病患病风险是非患者的4.99倍(OR=4.99,95%CI=4.17~5.98),高血压患者糖尿病患病风险是非患者的3.14倍(OR=3.14,95%CI=2.73~3.62)。当家族史合并1高时,以家族史合并高三酰甘油血症人群的糖尿病患病风险最高(OR=4.60,95%CI=4.01~5.29),当家族史合并2高时,以家族史合并高三酰甘油血症、超重肥胖人群的糖尿病患病风险最高(OR=4.67,95%CI=4.08~5.37),当家族史合并3高时,糖尿病患病风险达到最高(OR=5.72,95%CI=5.14~6.42)。结论家族史合并危险因素聚集越多,糖尿病患病风险越高,应及时做好干预工作。Objective To understand the relationship between family history of diabetes and clustered risk factors and diabetes,and to provide a reference for developing appropriate diabetes prevention strategies.Methods From October 2019 to April 2020,8981 permanent residents over age of 18 years were randomly selected by multi-stage random sampling in Haimen District,Nantong City,Jiangsu Province.Face to face questionnaire and physical examination were conducted on the subjects,and t-test,χ~2 test and multivariate logistic regression were used to study the influence of diabetes family history and risk factors aggregation on diabetes.Results 8350 residents were adapted,with the crude and standard prevalence rates of 11.2%and 5.4%,respectively.After adjusting for confounders such as gender,age,education,occupation,and total static time,the results of the multivariate logistic regression analysis showed that residents with following factors had an increased risk of diabetes:family history(OR=3.43,95%CI=2.86-4.11),overweight and obesity(OR=1.60,95%CI=1.39-1.83),senior hypertriglyceridemia(OR=4.99,95%CI=4.17-5.98),hypertension(OR=3.14,95%CI=2.73-3.62)compared to those without the exposures.The analysis also revealed that the residents with family history with one or more risk factors were at a much higher risk of diabetes,with the ORs of 4.60(95%CI=4.01-5.29)for those with family history and hypertriglyceridemia,4.67(95%CI=4.08-5.37)for those with family history and hypertriglyceridemia plus overweight,extremely 5.72(95%CI=5.14-6.42)for those with family history and other three risk factors.Conclusion The more family history combined with risk factors are gathered,the higher the risk of diabetes mellitus is.Intervention measure should be done well in time.

关 键 词：糖尿病 家族史 危险因素 

分 类 号：R587.1[医药卫生—内分泌]