脂肪源性干细胞在女性盆底功能障碍性疾病中的应用潜力  

Application potential of adipose-derived stem cells in female pelvic floor dysfunction diseases

作　　者：白思琪 肖祯[1] 刘晶[1] Bai Siqi;Xiao Zhen;Liu Jing(First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning Province,China)

机构地区：[1]大连医科大学附属第一医院,辽宁省大连市116011

出　　处：《中国组织工程研究》2023年第6期921-927,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:盆底功能障碍性疾病的发病率逐年上升,现有治疗方法存在疗效弊端。干细胞疗法在很多疾病的治疗方面具有巨大潜力,脂肪源性干细胞作为干细胞治疗的种子细胞,具有来源丰富、取材方便、增殖活性高、可多向分化、低免疫原性、易体外培养、能规避诸多伦理问题的独特优势,已成为备选细胞类型之一。目的:针对脂肪源性干细胞的特点、优势及现有研究,讨论其在女性盆底功能障碍性疾病,特别是尿失禁和便失禁中的应用潜力。方法:以“干细胞,脂肪源性干细胞,盆底功能障碍性疾病,压力性尿失禁,便失禁”“stem cells,adipose-derived stem cells,pelvic floor dysfunctions,stress urinary incontinence,anal incontinence”为检索词,检索CNKI、万方数据库、维普、PubMed数据库中发表过的363篇相关文献,通过筛选整理,排除与研究内容无关的文献、重复性研究和过早发表的文献,最终保留了55篇文献进行综述。结果与结论:脂肪源性干细胞依据其获取方便、自我更新快速、低免疫原性、高增殖率、向多谱系分化的潜力,有望为盆底功能障碍性疾病的治疗提供新的突破口。但是由于向临床转化过程中仍存在一些有待解决的问题,例如缺乏标准化的干细胞获取、培养、移植和移植后监测流程及规范,以及现有研究因样本量小、随访时间短等问题,致使脂肪源性干细胞在未来治疗盆底疾病将会是机遇与挑战并存。BACKGROUND:The incidence of pelvic floor dysfunctions is increasing year by year,and the existing treatment methods have disadvantages in curative effect.Stem cell therapy has a great potential in the treatment of many diseases.As seed cells for stem cell therapy,adipose-derived stem cells have become one of the alternative cell types with the unique advantages of rich sources,convenient acquisition,high proliferative activity,multi-directional differentiation,low immunogenicity,easy culture in vitro and avoiding many ethical problems.OBJECTIVE:To discuss the application potential of adipose-derived stem cells in female pelvic floor disorders,especially urinary incontinence and fecal incontinence according to the characteristics,advantages and existing research of adipose-derived stem cells.METHODS:The 363 related articles were searched on CNKI,Wanfang database,VIP database and PubMed database with“stem cells,adipose-derived stem cells,pelvic floor dysfunction diseases,stress urinary incontinence,anal incontinence”as the search terms.Through screening and sorting,the articles unrelated to the research contents,repetitive studies and prematurely published articles were excluded,and 55 articles were finally retained for review.RESULTS AND CONCLUSION:Adipose-derived stem cells are expected to provide a new breakthrough for the treatment of pelvic floor disorders according to their convenient access,rapid self-renewal,low immunogenicity,high proliferation rate,and the potential of multi-lineage differentiation.However,there are still some problems to be solved in the process of clinical transformation,such as the lack of standardized procedures and norms for stem cell acquisition,culture,transplantation and post-transplantation monitoring as well as the existing research due to small sample size,short follow-up time and other problems.Adipose-derived stem cells in the future treatment of pelvic floor dysfunctions will have both opportunities and challenges.

关 键 词：干细胞 脂肪源性干细胞 盆底功能障碍性疾病 压力性尿失禁 便失禁 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R71