α-硫辛酸联合葛根素注射液治疗糖尿病周围神经病变的疗效及对患者血液动力学的影响  

Efficacy of α-lipoic acid combined with puerarin injection in the treatment of diabetic peripheral neuropathy and the influence on hemodynamics

作　　者：武燕 任莎莎 杨露 WU Yan;REN Sha-sha;YANG Lu(Department of Neurology,Xianyang Hospital,Yan'an University,Xianyang 712000,Shaanxi,CHINA)

机构地区：[1]延安大学咸阳医院神经内科,陕西咸阳712000

出　　处：《海南医学》2022年第14期1773-1777,共5页Hainan Medical Journal

基　　金：陕西省中医药管理局科研课题(编号:2018-GJ-JC039)。

摘　　要：目的探讨α-硫辛酸联合葛根素注射液治疗糖尿病周围神经病变(DPN)的效果及对患者血液动力学的影响。方法选取2017年9月至2019年9月延安大学咸阳医院神经内科收治的60例DPN患者为研究对象,采用随机数表法分为对照组和观察组,每组30例,对照组患者给予葛根素治疗,观察组患者给予α-硫辛酸联合葛根素治疗,两组患者均持续治疗两周。比较两组患者治疗后的临床疗效,以及治疗前后的多伦多临床系统评分(TCSS)、总体症状评分(TSS)、氧化应激和炎症反应指标[C反应蛋白(CRP)、丙二醛(MDA)、超氧化物歧化酶(SOD)]、感觉神经传导速度、运动神经传导速度、血液动力学指标[全血高切黏度(HSV)、全血低切黏度(LSV)、血浆黏度(PSV)、血细胞比容(HCT)]及不良反应发生情况。结果观察组患者的治疗总有效率为93.33%,明显高于对照组的70.00%,差异具有统计学意义(P<0.05);治疗后,观察组患者的TSS、TCSS评分分别为(4.61±1.17)分、(4.02±0.23)分,明显低于对照组的(7.78±1.82)分和(6.91±1.45)分,差异均有统计学意义(P<0.05);治疗后,观察组患者的SOD为(45.23±8.40)U/L,明显高于对照组的(22.87±6.17)U/L,MDA和CRP分别为(2.51±0.33)nmol/L、(4.32±0.25)mg/L,明显低于对照组的(5.79±0.88)nmol/L、(7.51±1.37)mg/L,差异均有统计学意义(P<0.05);治疗后,观察组患者的感觉神经传导速度和运动神经传导速度明显快于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者的HSV、LSV、PSV及HCT明显低于对照组,差异均有统计学意义(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论α-硫辛酸联合葛根素治疗DPN可有效减轻患者的临床症状,改善神经功能、氧化应激水平及血液流变学水平,减少炎症反应,临床应用效果显著,且安全性较高。Objective To investigate the efficacy of α-lipoic acid combined with puerarin injection in the treatment of diabetic peripheral neuropathy(DPN),and to analyze its influence on hemodynamics in the patients.Methods Sixty patients with DPN admitted to the Department of Neurology,Xianyang Hospital,Yan'an University from September 2017 to September 2019 were selected as the study subjects.They were divided into a control group and an observation group by random number table method,with 30 patients in each group.Patients in the control group were treated with puerarin,while patients in the observation group were treated with α-lipoic acid combined with puerarin.Both groups of patients were given 2 weeks of treatment.The two groups were compared on clinical effect after treatment,the Toronto Clinical Scoring System(TCSS)scores,Total Symptoms Score(TSS)scores,oxidative stress,and inflammatory response indexes[C reactive protein(CRP),malondialdehyde(MDA),superoxide dismutase(SOD)],sensory nerve conduction velocity,motor nerve conduction velocity,and hemodynamic indexes[high shearviscosity(HSV),low shearviscosity(LSV),plasma specificviscosity(PSV),hematocrit(HCT)]before treatment and after treatment,and the incidence of adverse reactions.Results The treatment response rate in the observation group(93.33%)was significantly higher than that in the control group(70.00%),and the difference was statistically significant(P<0.05).After treatment,the TSS and TCSS scores of patients in the observation group were(4.61±1.17)points and(4.02±0.23)points,significantly lower than(7.78±1.82)points and(6.91±1.45)points of control group(P<0.05).After treatment,the SOD level of patients in the observation group was(45.23±8.40)U/L,significantly higher than(22.87±6.17)U/L in the control group,while the levels of MDA and CRP were(2.51±0.33)nmol/L and(4.32±0.25)mg/L,significantly lower than(5.79±0.88)nmol/L and(7.51±1.37)mg/L in the control group,with statistically significant differences(P<0.05).After treatment,the sensory nerve con

关 键 词：糖尿病 周围神经病变 Α-硫辛酸 葛根素 血液动力学 

分 类 号：R587.2[医药卫生—内分泌]