非雌激素药物与雌激素药物分别联合抗炎药治疗绝经后萎缩性阴道炎的疗效观察  

Curative effects of non-estrogenic drugs or estrogenic drugs combined with anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis

作　　者：冯若梅 李秋云 陈云侠 赵延红[2] 董海鹏 FENG Ruo-mei;LI Qiu-yun;CHEN Yun-xia;ZHAO Yan-hong;DONG Hai-peng(Department of Clinical Pharmacy,Tongchuan People's Hospital,Tongchuan 727000,Shaanxi,CHINA;Department of Department of Clinical Pharmacy,Yan'an People's Hospital,Yan'an 716000,Shaanxi,CHINA)

机构地区：[1]铜川市人民医院临床药学科,陕西铜川727000 [2]延安市人民医院临床药学科,陕西延安716000

出　　处：《海南医学》2022年第14期1828-1831,共4页Hainan Medical Journal

摘　　要：目的探讨非雌激素药物与雌激素药物分别联合抗炎药治疗绝经后萎缩性阴道炎的临床疗效,为绝经后萎缩性阴道炎患者用药选择提供参考。方法选取2019年1月至2020年1月铜川市人民医院诊治的98例绝经后萎缩性阴道炎患者为研究对象,采用随机数表法分为雌激素组和非雌激素组,每组49例。非雌激素组患者给予非雌激素药物联合抗炎药治疗,雌激素组患者给予雌激素药物联合抗炎药治疗,两组均持续治疗1个月。疗程结束后,比较两组患者的治疗效果,以及治疗前后的血清性激素水平[雌二醇(E2)、促卵泡激素(FSH)和黄体生成激素(LH)]和症状评分(采用阴道健康评分评估),同时比较两组患者治疗期间的不良反应及随访治疗后6个月内复发率。结果雌激素组患者的治疗总有效率为95.92%,略高于非雌激素组的91.84%,但差异无统计学意义(P>0.05);两组患者治疗前后以及治疗后的FSH、LH、E2水平比较差异均无统计学意义(P>0.05):与治疗前比较,治疗后两组患者的临床症状评分明显降低,差异均有统计学意义(P<0.05),但两组患者治疗后的各项症状评分比较差异均无统计学意义(P>0.05);雌激素组患者治疗期间的不良反应总发生率为12.24%,略高于非雌激素组的10.20%,6个月复发率为6.12%,略低于非雌激素组的8.16%,但差异均无统计学意义(P>0.05)。结论非雌激素药物与雌激素药物分别联合抗炎药治疗绝经后萎缩性阴道炎患者的临床疗效相当,其中非雌激素药物联合抗炎药治疗可作为排斥激素用药患者的一种安全有效的替代疗法。Objective To investigate the clinical effects of non-estrogenic drugs or estrogenic drugs combined with anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis,so as to provide reference for the choice of drugs in patients with postmenopausal atrophic vaginitis.Methods A total of 98 patients with postmenopausal atrophic vaginitis admitted to Tongchuan People's Hospital from January 2019 to January 2020 were selected as the research subjects.They were divided into estrogen group and non-estrogen group by random number table method,with 49 patients in each group.Patients in non-estrogen group were treated with non-estrogenic drugs combined with anti-inflammatory drugs,while patients in estrogen group were treated with estrogenic drugs combined with anti-inflammatory drugs,all for 1 month.After treatment,the therapeutic effect,serum sex hormone levels[estradiol(E2),follicle stimulating hormone(FSH),and luteinizing hormone(LH)]and symptom scores(evaluated by vaginal health score)before and after treatment were compared between the two groups.At the same time,the adverse reactions during treatment and the recurrence rate within 6 months after follow-up were compared between the two groups.Results The total response rate of treatment in estrogen group was 95.92%,which was slightly higher than 91.84%in non-estrogen group,with no statistically significant difference(P>0.05).There were no statistically significant differences in FSH,LH,and E2levels between the two groups before and after treatment(P>0.05).Compared with before treatment,the clinical symptom scores of the two groups were significantly decreased after treatment,and the differences were statistically significant(P<0.05);however,there was no significant difference in the post-treatment symptom scores(P>0.05).The total incidence of adverse reactions in estrogen group during treatment was 12.24%,which was slightly higher than 10.20%in non-estrogen group,and the recurrence rate within 6 months was 6.12%,which was slightly lower than 8.16%in

关 键 词：萎缩性阴道炎 绝经 抗炎 非雌激素 雌激素 疗效 

分 类 号：R711.31[医药卫生—妇产科学]