遵义地区4604例住院新生儿TORCH感染状况分析  

Analysis of TORCH infection status of 4604 hospitalized neonates in Zunyi area

作　　者：袁志美 吴佳桃 邱成楷 杨钰欣[1] 李雪平 YUAN Zhimei;WU Jiatao;QIU Chengkai;YANG Yuxin;LI Xueping(Department of Laboratory Medicine,Zunyi Maternal and Child Health Hospital,Zunyi 563000,China)

机构地区：[1]遵义市妇幼保健院检验科,遵义563000

出　　处：《广州医药》2022年第4期5-8,25,共5页Guangzhou Medical Journal

基　　金：遵义市科技计划项目[遵义科合社字项目(2018)220号]。

摘　　要：目的了解遵义地区住院新生儿TORCH感染状况、发病率,为相关疾病的早期预防和治疗提供重要参考依据。方法采用回顾性研究方法,对遵义市妇幼保健院2018—2019年住院新生儿弓形虫(TOX)、风疹(RV)、巨细胞(CMV)和单纯疱疹病毒(HSV)Ⅰ型感染结果进行分析。结果遵义地区4604例住院新生儿TORCH-IgM的总体阳性率为1.35%,其中CMV、TOX、RV、HSVⅠ的阳性率分别是1.00%、0.20%、0.13%和0.02%;对应TORCH-IgG的阳性率分别是67.38%、0.91%,54.54%、22.22%。对2018—2019年住院新生儿TORCH感染筛查结果显示:CMV-IgM阳性率分别从1.47%下降到0.43%(χ^(2)=4.981,P=0.026),RV-IgM的阳性率从0.24%下降到0.00(χ^(2)=12.446,P<0.001),差异均有统计学意义。在研究的2607例男性患儿中,CMV、TOX、RV、HSVⅠ的IgM阳性率率分别是0.19%、0.11%、0.96%和0.04%,其IgG的阳性率为1.07%、55.20%、67.93%和22.48%。在研究的1997例女性患儿中,CMV、TOX、RV、HSVⅠ的IgM阳性率分别是0.20%、0.15%、1.05%和0.00%,其IgG的阳性率为0.70%、53.68%、66.65%和21.88%。不同CMV-IgM感染对谷丙转氨酶(ALT)和谷草转氨酶(AST)的活性影响研究中,CMV-IgM抗体阳性对照组的ALT活性高于阴性组(t=-2.793,P<0.05),AST的活性无差异(t=0.067,P>0.05)结论遵义地区4604例住院新生儿中以CMV感染率相对较高,不容忽视。2018—2019年CMV和RV的新近感染率呈下降趋势。CMV-IgM的感染能引起ALT活性的升高。Objective To reveal the TORCH infection status and incidence of hospitalized newborns in Zunyi area,and provide important reference for early prevention and treatment of related diseases.Methods The retrospective research method was used to analyze the infection results of toxoplasma gondii(TOX),rubella virus(RV),cytomegalovirus(CMV)and herpes simplx virus(HSV)type I in hospitalized newborns in Zunyi Maternal and Child Health Hospital from 2018 to 2019.Results The overall positive rate of TORCH-IgM in 4604 hospitalized newborns in Zunyi area was 1.35%,of which the positive rates of CMV,TOX,RV,and HSVⅠ were 1.00%,0.20%,0.13% and 0.02%,respectively;the corresponding TORCH-IgG positive rates were 67.38%,0.91%,54.54%,22.22%.The TORCH infection screening results of neonates hospitalized in 2018—2019 showed that the CMV-IgM positive rate decreased from 1.47%to 0.43%(χ^(2)=4.981,P=0.026),and the RV-IgM positive rate decreased from 0.24%to 0.00(χ^(2)=12.446,P<0.001),the differences were statistically significant.In 2607 male children,the IgM positive rates of CMV,TOX,RV and HSVⅠ were 0.19%,0.11%,0.96% and 0.04%,respectively;and the corresponding IgG positive rates were 1.07%,55.20%,67.93% and 22.48%.In 1997 female children,the IgM positive rates of CMV,TOX,RV and HSVⅠ were 0.20%,0.15%,1.05% and 0.00,respectively;and the corresponding IgG positive rate was 0.70%,53.68%,66.65% and 21.88%.In the study of effects of different CMV-IgM infection on alanine aminotransferase(ALT)and aspartate aminotransferase(AST)activity,the ALT activity of CMV-IgM positive group was significantly higher than that of negative group(t=-2.793,P<0.05),and there was no difference in AST activity between the two groups(t=0.067,P>0.05).Conclusions The CMV infection rate among 4604 hospitalized newborns in Zunyi area was relatively high,which should not be ignored.The recent infection rates of CMV and RV showed a downward trend from 2018 to 2019.CMV-IgM infection could cause an increase in ALT activity.

关 键 词：TORCH 住院新生儿 感染率 ALT 

分 类 号：R722.13[医药卫生—儿科]