非糖尿病人群的长期空腹血糖变异性与心脑血管事件的相关性  

Relationship Between Long-term Fasting Blood Glucose Variability and Cardio-cerebrovascular Events in Non-diabetic Population

作　　者：穆瑞娲[1] 朱辰蕊[2] 杜鑫[2] 韩旭 汪国栋[3] 陈朔华[3] 林黎明[2] 李慧英[2] 赵秀娟 魏晓明[2] 季春鹏[2] 黄喆[2] 吴寿岭[2] MU Ruiwa;ZHU Chenrui;DU Xin;HAN Xu;WANG Guodong;CHEN Shuohua;LIN Liming;LI Huiying;ZHAO Xiujuan;WEI Xiaoming;JI Chunpeng;HUANG Zhe;WU Shouling(Department of Plastic Surgery,Kailuan General Hospital,Tangshan(063000),Hebei,China)

机构地区：[1]开滦总医院整形科,河北省唐山市063000 [2]开滦总医院心内科,河北省唐山市063000 [3]开滦总医院心血管病实验室,河北省唐山市063000

出　　处：《中国循环杂志》2022年第7期701-707,共7页Chinese Circulation Journal

摘　　要：目的:探讨非糖尿病人群的长期空腹血糖(FBG)变异性(FBGV)与心脑血管事件的相关性。方法:选取开滦研究参加2006-2007年体检后至少参加2008-2009年、2010-2011年、2012-2013年任意两次随访的人群作为观察对象,计算并使用FBG标准差(SD)和变异系数(CV)来定义FBGV,并根据FBGV四分位数将观察对象分成四组,以计算变异性的末次体检时间为随访起点。采用Cox风险比例模型探讨非糖尿病人群FBGV分组、FBGV每增加1个SD与心脑血管事件风险的相关性。结果:最终符合纳入标准的观察对象共62 019例,随访6.76(6.45,7.14)年期间,发生心脑血管事件2 661例。与FBG-SD、FBG-CV第一四分位组人群相比,第四四分位组人群发生心脑血管事件的风险分别增加15%和12%[HR(95%CI)分别为:1.15(1.03-1.28)、1.12(1.00-1.24)];FBG-SD、FBG-CV每增加1个SD,心脑血管事件发生风险均增加7%[HR(95%CI)分别为:1.07(1.04-1.11)、1.07(1.03-1.10)]。结论:非糖尿病人群的长期FBGV与心脑血管事件发生风险呈正向关联。Objectives: To explore the relationship between long-term fasting blood glucose(FBG) variability(FBGV) and cardiocerebrovascular events in non-diabetic population.Methods: This is a prospective cohort study. People who attended the 2006-2007 physical examination of Kailuan Group Company and finished at least 2 follow-up visits in 2008-2009, 2010-2011, 2012-2013 physical examination were eligible for this study. FBGV was calculated using standard deviation(SD) and coefficient of variation(CV). Participants were divided into 4 groups according to quartile of FBGV. The time of the last physical examination for calculating FBGV was taken as the starting point of follow-up. Cox regression model was used to determine the association between FBGV groups, every 1 SD increased in FBGV and the risk of cardiovascular and cerebrovascular events.Results: A total of 62 019 subjects were included in this study. After a median follow-up of 6.76(6.45, 7.14)years, cardio-cerebrovascular events were reported in 2 661 cases. After adjustment for age, sex, body mass index, lowdensity lipoprotein cholesterol, smoking, alcohol consumption, physical exercise, history of hypertension, education and baseline FBG, compared with the first quantile group, the Cox regression model showed that HRs of the fourth group in FBGSD and FBG-CV were 1.15(95% CI: 1.03-1.28) and 1.12(95% CI: 1.00-1.24), respectively. HRs of every 1 SD increased in FBG-SD and FBG-CV were 1.07(95% CI: 1.04-1.11) and 1.07(95% CI: 1.03-1.10), respectively.Conclusions: FBGV is positively associated with the risk of cardio-cerebrovascular events in non-diabetic population.

关 键 词：空腹血糖 空腹血糖变异性 心脑血管事件 非糖尿病人群 

分 类 号：R54[医药卫生—心血管疾病]