口服钙剂时间及剂量对献血者机采血小板过程中枸橼酸钠反应的影响  

Effects of oral calcium dosage and time on sodium citrate response during platelet collection from blood donors

作　　者：梁丽华 陈超红 陈存意 梁洁贞 廖君艳 梁婷 梁伟英 LIANG Lihua;CHEN Chaohong;CHEN Cunyi;LIANG Jiezhen;LIAO Junyan;LIANG Ting;LIANG Weiying(Zhaoqing Central Blood Station,Guangdong Province,Zhaoqing526020,China)

机构地区：[1]广东省肇庆市中心血站,广东肇庆526020

出　　处：《中国当代医药》2022年第19期35-37,共3页China Modern Medicine

基　　金：广东省肇庆市科技计划项目(202004031466)。

摘　　要：目的探讨口服钙剂时间及剂量对献血者机采血小板过程中枸橼酸钠反应的影响。方法选取2020年4月至2021年3月肇庆市参加机采血小板捐献的400名献血者作为研究对象,采用随机数字表法将所有研究对象分为A、B、C、D共四组,每组100人。A组为对照,采血前及采集过程不采取任何干预措施;B组采血前30 min口服钙剂20 ml;C组采血前10 min口服钙剂20 ml;D组采血前10 min口服钙剂20 ml,采集中段及采集结束前10 min各加服钙剂10 ml。观察四组献血者出现枸橼酸钠反应的情况,一直至采集结束。比较不同的口服钙剂时间及剂量对献血者枸橼酸钠反应的影响。结果四组献血者的枸橼酸钠反应发生率比较,差异有统计学意义(χ^(2)=29.575,P<0.001)。A、B组的枸橼酸钠反应发生率高于D组,差异有统计学意义(分别为χ^(2)=19.198,P<0.001;χ^(2)=10.288,P=0.001);A组与B组、A组与C组、B组与C组、C组与D组的枸橼酸钠反应发生率比较,差异均无统计学意义(分别为χ^(2)=1.754,P=0.185;χ^(2)=5.570,P=0.018;χ^(2)=1.276,P=0.259;χ^(2)=4.712,P=0.030)。结论在服用20 ml钙剂10 min后采血,在采集中段及采血结束前10 min再加服钙剂10 ml的方法能够有效降低枸橼酸钠反应。Objective To investigate the effect of oral calcium time and dose on sodium citrate reaction during platelet collection by blood donors.Methods A total of 400 blood donors who participated in platelet donation from April 2020 to March 2021 in Zhaoqing were selected as the research objects,they were divided into A,B,C,D group by random number table method,with 100 cases in each group.Group A was the control group,no intervention measures were taken before and during collection.Group B took 20 ml calcium orally 30 min before collection.In group C,20 ml calcium was taken orally 10 min before collection.In group D,20 ml calcium was taken orally 10 min before blood collection,10 ml calcium was added in the middle of collection and 10 min before the end of collection.The incidence of sodium citrate reaction in four groups were observed until the end of collection.The effects of different oral calcium time and dose on the response of blood donors to sodium citrate were compared.Results There was significant difference in the incidence of sodium citrate reaction among the four groups,and the difference was statistically significant(P<0.001).The incidence of sodium citrate reaction in group A and group B was higher than that in group D,the differences were statistically significant(χ^(2)=19.198,P<0.001;χ^(2)=10.288,P=0.001).There were no significant differences in the incidence of sodium citrate reaction between group A and group B,between group A and group C,between group B and group C,and between group C and group D(χ^(2)=1.754,P=0.185;χ^(2)=5.570,P=0.018;χ^(2)=1.276,P=0.259;χ^(2)=4.712,P=0.030).Conclusion Taking blood 10 min after taking 20 ml of calcium,and taking 10 ml of calcium in the middle of collection and 10 min before the end of blood collection can effectively reduce sodium citrate reaction.

关 键 词：献血 钙剂 时间 剂量 枸橼酸钠反应 

分 类 号：R595.4[医药卫生—内科学]