雷公藤多苷片联合卡格列净治疗糖尿病肾病的临床效果  

Clinical effect of Tripterygium Glycoside Tablets combined with Canag-liflozin in the treatment of diabetic nephropathy

作　　者：翟博娜 郝建荣[1] ZHAI Bona;HAO Jianrong(Department of Nephrology,Beijing Jingmei Group General Hospital,Beijing102300,China)

机构地区：[1]北京京煤集团总医院肾内科,北京102300

出　　处：《中国当代医药》2022年第19期109-111,115,共4页China Modern Medicine

摘　　要：目的探讨雷公藤多苷片联合卡格列净治疗糖尿病肾病(DN)的临床效果。方法选取2020年1月至2021年6月北京京煤集团总医院肾内科收治的DN患者80例作为研究对象进行回顾性分析,根据不同治疗方式将其分为对照组(n=40)与观察组(n=40)。对照组患者采用卡格列净治疗,观察组患者采用雷公藤多苷片联合卡格列净治疗,两组患者均治疗3个月。比较两组患者治疗前后的肾功能[24 h尿蛋白定量(24-UP)、尿氮素(BUN)、血肌酐(SCr)]、肝功能[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)]及白细胞计数(WBC)。结果治疗后,两组患者的24-UP、BUN及SCr水平均低于治疗前,且观察组患者的24-UP、BUN及SCr水平均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后的ALT、AST、WBC组间及组内比较,差异无统计学意义(P>0.05)。结论雷公藤多苷片联合卡格列净治疗DN患者的效果优于单药卡格列净,对其肾功能有一定改善作用。Objective To investigate the clinical effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the treatment of diabetic nephropathy(DN).Methods A total of 80 patients with DN admitted to Department of Nephrology in Beijing Jingmei Group General Hospital from January 2020 to June 2021 were selected as the research objects,and they were divided into the control group(n=40)and the observation group(n=40)according to different treatment methods.The retrospective analysis was used in this study.The control group was treated with Canagliflozin,and the observation group was treated with Tripterygium Glycoside Tablets combined with Canagliflozin.Both groups were treated for three months.The renal function(24-h quantitative of urinary protein[24-UP],blood urea nitrogen[BUN],serum creatinine[SCr]),liver function(alanine aminotransferase[ALT],aspartate aminotransferase[AST])and white blood cell count(WBC)before and after treatment were compared between the two groups.Results After treatment,the levels of 24-UP,BUN and SCr in the two groups were lower than those before treatment,and the levels of 24-UP,BUN and SCr in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in ALT,AST,WBC between and within the two groups before and after treatment(P>0.05).Conclusion The effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the treatment of DN patients is better than that of Canagliflozin alone,and it can improve their renal function to some extent.

关 键 词：糖尿病肾病 雷公藤多苷片 卡格列净 临床效果 

分 类 号：R587.2[医药卫生—内分泌]